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dldh dihydrolipoamide dehydrogenase [ Danio rerio (zebrafish) ]

Gene ID: 399479, updated on 20-May-2023

Summary

Official Symbol
dldhprovided by ZNC
Official Full Name
dihydrolipoamide dehydrogenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040120-4
See related
Ensembl:ENSDARG00000008785 AllianceGenome:ZFIN:ZDB-GENE-040120-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb24b05; wu:fb24b05
Summary
Predicted to enable dihydrolipoyl dehydrogenase activity and flavin adenine dinucleotide binding activity. Acts upstream of or within heart contraction. Predicted to be located in acrosomal vesicle and motile cilium. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including adaxial cell; digestive system; midbrain; musculature system; and retina. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See dldh in Genome Data Viewer
Location:
chromosome: 25
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (26877705..26892990, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (26434503..26449788, complement)
103 previous assembly Zv9 (GCF_000002035.4) 25 NC_007136.5 (27744409..27759694, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene COMM domain containing 4 Neighboring gene semaphorin 7A Neighboring gene si:dkey-42p14.3 Neighboring gene zinc finger protein 800a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dihydrolipoyl dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dihydrolipoyl dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dihydrolipoyl dehydrogenase, mitochondrial
NP_958914.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201506.1NP_958914.1  dihydrolipoyl dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_958914.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044432
    UniProtKB/TrEMBL
    Q803L1
    Related
    ENSDARP00000017217.6, ENSDART00000006709.7
    Conserved Domains (5) summary
    PRK06327
    Location:42507
    PRK06327; dihydrolipoamide dehydrogenase; Validated
    pfam00070
    Location:214286
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:388494
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl10013
    Location:282376
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl21454
    Location:44220
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    26877705..26892990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)