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dld deltaD [ Danio rerio (zebrafish) ]

Gene ID: 399479, updated on 19-May-2025
Official Symbol
dldprovided by ZNC
Official Full Name
deltaDprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-47
See related
Ensembl:ENSDARG00000008785 AllianceGenome:ZFIN:ZDB-GENE-990415-47
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables PDZ domain binding activity. Acts upstream of or within several processes, including determination of left/right symmetry; somite development; and ventral spinal cord development. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including gut; mesoderm; nervous system; presumptive mesoderm; and tail bud. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, May 2025]
Orthologs
human mouse all
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See dld in Genome Data Viewer
Location:
chromosome: 25
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (29223197..29238482, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (26877705..26892990, complement)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene COMM domain containing 4 Neighboring gene semaphorin 7A (JohnMiltonHagen blood group) Neighboring gene si:dkey-42p14.3 Neighboring gene zinc finger protein 800a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish. Lee H, et al. J Hazard Mater, 2021 Aug 15. PMID 34492873
  2. dldhcri3 zebrafish exhibit altered mitochondrial ultrastructure, morphology, and dysfunction partially rescued by probucol or thiamine. Lavorato M, et al. JCI Insight, 2024 Aug 20. PMID 39163131, Free PMC Article
  3. Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis. Chen W, et al. Dev Biol, 2004 Mar 15. PMID 15013799
  4. Zebrafish Numb homologue: phylogenetic evolution and involvement in regulation of left-right asymmetry. Niikura Y, et al. Mech Dev, 2006 May. PMID 16701985
  5. Interactions between muscle fibers and segment boundaries in zebrafish. Henry CA, et al. Dev Biol, 2005 Nov 15. PMID 16225858

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables PDZ domain binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Notch signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lateral inhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sclerotome development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within somatic motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
dihydrolipoyl dehydrogenase, mitochondrial
Names
dihydrolipoamide dehydrogenase
NP_958914.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201506.1 → NP_958914.1  dihydrolipoyl dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_958914.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044432
    UniProtKB/TrEMBL
    Q803L1
    Related
    ENSDARP00000017217.6, ENSDART00000006709.7
    Conserved Domains (5) summary
    PRK06327
    Location:42 → 507
    PRK06327; dihydrolipoamide dehydrogenase; Validated
    pfam00070
    Location:214 → 286
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:388 → 494
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl10013
    Location:282 → 376
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl21454
    Location:44 → 220
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    29223197..29238482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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