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SPRED3 sprouty related EVH1 domain containing 3 [ Homo sapiens (human) ]

Gene ID: 399473, updated on 23-Nov-2021

Summary

Official Symbol
SPRED3provided by HGNC
Official Full Name
sprouty related EVH1 domain containing 3provided by HGNC
Primary source
HGNC:HGNC:31041
See related
Ensembl:ENSG00000188766 MIM:609293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Eve-3; spred-3
Summary
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in brain (RPKM 1.8), duodenum (RPKM 0.4) and 14 other tissues See more
Orthologs
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Genomic context

See SPRED3 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38388697..38399587)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38880840..38890524)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene gametogenetin Neighboring gene family with sequence similarity 98 member C Neighboring gene RAS guanyl releasing protein 4 Neighboring gene ryanodine receptor 1 Neighboring gene uncharacterized LOC107985290

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • AC005789.11

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sprouty-related, EVH1 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042522.3NP_001035987.1  sprouty-related, EVH1 domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001035987.1

    Status: REVIEWED

    Source sequence(s)
    AC005789
    Consensus CDS
    CCDS42560.1
    UniProtKB/Swiss-Prot
    Q2MJR0
    UniProtKB/TrEMBL
    B9EKV1
    Related
    ENSP00000345405.4, ENST00000338502.8
    Conserved Domains (2) summary
    cd10574
    Location:2105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:296400
    Sprouty; Sprouty protein (Spry)
  2. NM_001394336.1NP_001381265.1  sprouty-related, EVH1 domain-containing protein 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC005789
    Conserved Domains (2) summary
    cd10574
    Location:2105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:296400
    Sprouty; Sprouty protein (Spry)
  3. NM_001394337.1NP_001381266.1  sprouty-related, EVH1 domain-containing protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC005789
    Conserved Domains (1) summary
    cd10574
    Location:2105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
  4. NM_001394338.1NP_001381267.1  sprouty-related, EVH1 domain-containing protein 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005789

RNA

  1. NR_073032.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005789

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38388697..38399587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526978.2XP_011525280.1  sprouty-related, EVH1 domain-containing protein 3 isoform X2

    Conserved Domains (2) summary
    pfam05210
    Location:265362
    Sprouty; Sprouty protein (Spry)
    cl17171
    Location:274
    PH-like; Pleckstrin homology-like domain
  2. XM_006723219.3XP_006723282.1  sprouty-related, EVH1 domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006723282.1

    UniProtKB/Swiss-Prot
    Q2MJR0
    Conserved Domains (2) summary
    cd10574
    Location:2105
    EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    pfam05210
    Location:296400
    Sprouty; Sprouty protein (Spry)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039616.1: Suppressed sequence

    Description
    NM_001039616.1: This RefSeq was suppressed because currently there is insufficient support for the transcript and the protein.
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