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CG12229 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39945, updated on 6-Jul-2026
Official Symbol
CG12229provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036723
Locus tag
Dmel_CG12229
See related
AllianceGenome:FB:FBgn0036723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12229
Summary
Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CG12229 in Genome Data Viewer
Location:
74C1-74C1; 3-45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17434472..17436431, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17427572..17429531, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Golgin, RAB6 interacting Neighboring gene Coenzyme Q4 Neighboring gene fringe connection Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44565

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Developmental inhibition of miR-iab8-3p disrupts mushroom body neuron structure and adult learning ability. Busto GU, et al. Dev Biol, 2016 Nov 15. PMID 27634569, Free PMC Article
  2. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. Heidarian Y, et al. G3 (Bethesda), 2023 Dec 29. PMID 37792629, Free PMC Article
  3. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article
  4. In silico identification and analysis of paralogs encoding enzymes of carbohydrate metabolism in Drosophila melanogaster. Zaru R, et al. MicroPubl Biol, 2025. PMID 39975507, Free PMC Article
  5. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. Zhou D, et al. PLoS Genet, 2008 Oct. PMID 18927626, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables pyruvate kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
uncharacterized protein
Names
CG12229-PA
pyruvate kinase
NP_648980.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17434472..17436431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140723.1 → NP_648980.1  uncharacterized protein Dmel_CG12229

    See identical proteins and their annotated locations for NP_648980.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYR0, Q9VVH0
    Related
    FBpp0074988, FBtr0075226
    Conserved Domains (2) summary
    TIGR01064
    Location:103 → 530
    pyruv_kin; pyruvate kinase
    cl23794
    Location:126 → 530
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVH0 Q9VVH0

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