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bmp4.S bone morphogenetic protein 4 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399322, updated on 4-Nov-2024

Summary

Official Symbol
bmp4.S
Official Full Name
bone morphogenetic protein 4 S homeolog
Primary source
Xenbase:XB-GENE-6254046
Locus tag
XELAEV_18041226mg
See related
EnsemblRapid:ENSXLAG00005003605 AllianceGenome:Xenbase:XB-GENE-6254046
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
bmp4; zyme; DVR-4; bmp2b; ofc11; xbmp4; XBMP-4; bmp2b1; bmp4-a; bmp4-b
Summary
Predicted to enable cytokine activity and growth factor activity. Predicted to act upstream of or within several processes, including BMP signaling pathway; cartilage development; and ossification. Predicted to be located in extracellular space. Is expressed in cardiovascular system; ectoderm; vestibuloauditory system; and visual system. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See bmp4.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (13798305..13804047)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (13731520..13737130)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene glia maturation factor beta Neighboring gene cornichon family member 1 S homeolog Neighboring gene DDHD domain containing 1 S homeolog Neighboring gene FERM domain containing kindlin 2 S homeolog

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bone morphogenetic protein 4
Names
BMP-4
bone morphogenetic protein-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101793.1NP_001095263.1  bone morphogenetic protein 4 precursor

    See identical proteins and their annotated locations for NP_001095263.1

    Status: PROVISIONAL

    Source sequence(s)
    X63426
    UniProtKB/Swiss-Prot
    P30885
    UniProtKB/TrEMBL
    A0A974H594, B7ZPR8, O73818, Q6PAF3
    Conserved Domains (2) summary
    pfam00019
    Location:299400
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:48272
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    13798305..13804047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018231931.2XP_018087420.1  bone morphogenetic protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8J0TPC4, O73818, Q6PAF3
    Related
    ENSXLAP00005010733.1, ENSXLAT00005010901.1