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brv2 brivido-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39932, updated on 4-Jan-2025

Summary

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Official Symbol
brv2provided by FlyBase
Official Full Name
brivido-2provided by FlyBase
Primary source
FLYBASE:FBgn0036712
Locus tag
Dmel_CG16793
See related
AllianceGenome:FB:FBgn0036712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Brivido 2; Brivido2; Brv-2; Brv2; CG16793; CT33194; Dmel\CG16793
Summary
Predicted to enable calcium channel activity. Involved in cellular response to cold and detection of temperature stimulus involved in thermoception. Predicted to be active in membrane. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; and dorsal ectoderm anlage. Orthologous to human PKD1L2 (polycystin 1 like 2 (gene/pseudogene)); PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting); and PKDREJ (polycystin family receptor for egg jelly). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See brv2 in Genome Data Viewer
Location:
74A5-74A5; 3-45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17342050..17344696, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17335150..17337796, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Proline-CGG 2-2 Neighboring gene uncharacterized protein Neighboring gene Myoinhibiting peptide precursor Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Correcting locomotion dependent observation biases in thermal preference of Drosophila. Giraldo D, et al. Sci Rep, 2019 Mar 8. PMID 30850647, Free PMC Article
  2. The coding of temperature in the Drosophila brain. Gallio M, et al. Cell, 2011 Feb 18. PMID 21335241, Free PMC Article
  3. Ionotropic Receptors Specify the Morphogenesis of Phasic Sensors Controlling Rapid Thermal Preference in Drosophila. Budelli G, et al. Neuron, 2019 Feb 20. PMID 30654923, Free PMC Article
  4. Temperature sensation in Drosophila. Barbagallo B, et al. Curr Opin Neurobiol, 2015 Oct. PMID 25616212, Free PMC Article
  5. Feeling Hot and Cold: Thermal Sensation in Drosophila. Li K, et al. Neurosci Bull, 2017 Jun. PMID 27995563, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cellular response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of temperature stimulus involved in thermoception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
brivido-2
Names
Brivido-2
CG16793-PA
CG16793-PB
brv2-PA
brv2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17342050..17344696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275053.1 → NP_001261982.1  brivido-2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFT4
    Conserved Domains (1) summary
    pfam08016
    Location:147 → 574
    PKD_channel; Polycystin cation channel

  2. NM_140713.2 → NP_648970.2  brivido-2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648970.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8Z2, Q9VVF6
    Related
    FBpp0075004
    Conserved Domains (1) summary
    pfam08016
    Location:169 → 596
    PKD_channel; Polycystin cation channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PFT4 M9PFT4
Q8T8Z2 Q8T8Z2

Gene LinkOut

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