U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fzd3.L frizzled class receptor 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399190, updated on 5-Sep-2025
Official Symbol
fzd3.L
Official Full Name
frizzled class receptor 3 L homeolog
Primary source
Xenbase:XB-GENE-865070
Locus tag
XELAEV_18028255mg
See related
EnsemblRapid:ENSXLAG00005010061 AllianceGenome:Xenbase:XB-GENE-865070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
fz3; frz3; fzd3; frz-3; frizzled3
Summary
Enables protein serine/threonine kinase activity. Acts upstream of with a negative effect on establishment of planar polarity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and regulation of protein localization. Predicted to be located in apical plasma membrane and cell surface. Is expressed in ectoderm; mesoderm; nervous system; vestibuloauditory system; and visual system. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
NEW
Try the new Gene table
Try the new Transcript table
See fzd3.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
7
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (163818056..163875917, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (152780341..152838681, complement)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 9 L homeolog Neighboring gene exostosin like glycosyltransferase 3 L homeolog Neighboring gene F-box protein 16 L homeolog Neighboring gene elongator acetyltransferase complex subunit 3 L homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system. Shi DL, et al. Mech Dev, 1998 Jan. PMID 9510023
  2. Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate. Chuykin I, et al. J Cell Sci, 2021 Dec 15. PMID 34806749, Free PMC Article
  3. Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis. Kibardin A, et al. Development, 2006 Aug. PMID 16790480, Free PMC Article
  4. The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. Umbhauer M, et al. EMBO J, 2000 Sep 15. PMID 10990458, Free PMC Article
  5. Topologically correct central projections of tetrapod inner ear afferents require Fzd3. Duncan JS, et al. Sci Rep, 2019 Jul 16. PMID 31311957, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate.
    Title: Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate.
  2. Topologically correct central projections of tetrapod inner ear afferents require Fzd3.
    Title: Topologically correct central projections of tetrapod inner ear afferents require Fzd3.
  3. loss of Fzd3 induces severe malformations of the developing eye and this defect is phenocopied by loss of the activated leukocyte cell adhesion molecule (Alcam).
    Title: Frizzled 3 acts upstream of Alcam during embryonic eye development.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_negative_effect establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural crest cell fate specification TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
frizzled-3
Names
frizzled family receptor 3
frizzled homolog 3
fz-3
xfz3

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090449.1 → NP_001083918.1  frizzled-3 precursor

    See identical proteins and their annotated locations for NP_001083918.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ001754
    UniProtKB/Swiss-Prot
    O42579
    UniProtKB/TrEMBL
    A0A974CZB2, B7ZQS8
    Related
    ENSXLAP00005029638.1, ENSXLAT00005030384.1
    Conserved Domains (2) summary
    cd07449
    Location:23 → 149
    CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
    pfam01534
    Location:192 → 511
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    163818056..163875917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O42579.1 GenPept UniProtKB/Swiss-Prot:O42579

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials