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stk11.L serine/threonine kinase 11 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 399100, updated on 5-Sep-2025
Official Symbol
stk11.L
Official Full Name
serine/threonine kinase 11 L homeolog
Primary source
Xenbase:XB-GENE-955285
Locus tag
XELAEV_18006243mg
See related
EnsemblRapid:ENSXLAG00005015848 AllianceGenome:Xenbase:XB-GENE-955285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
LKB1; eek1; stk11; xeek1
Summary
Predicted to enable p53 binding activity and protein kinase activator activity. Predicted to act upstream of or within several processes, including glucose homeostasis; intrinsic apoptotic signaling pathway by p53 class mediator; and protein autophosphorylation. Predicted to be located in cytosol; membrane; and mitochondrion. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; cervical mucinous adenocarcinoma; familial melanoma; ovarian carcinoma; and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Jul 2025]
Annotation information
Annotation category: partial on reference assembly
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See stk11.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (108883993..108915525, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (96860846..96892317, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit delta L homeolog Neighboring gene CACN subunit beta associated regulatory protein L homeolog Neighboring gene uncharacterized LOC121400942 Neighboring gene uncharacterized LOC121400943

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos. Su JY, et al. J Biol Chem, 1996 Jun 14. PMID 8662877
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine/threonine-protein kinase stk11
Names
egg and embryo kinase 1
liver kinase B1 homolog
serine/threonine-protein kinase 11
serine/threonine-protein kinase XEEK1
NP_001083758.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001090289.1 → NP_001083758.1  serine/threonine-protein kinase stk11

    See identical proteins and their annotated locations for NP_001083758.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077243
    UniProtKB/Swiss-Prot
    Q6DE91, Q91604
    UniProtKB/TrEMBL
    A0A974DZS4
    Related
    ENSXLAP00005046621.1, ENSXLAT00005047725.1
    Conserved Domains (2) summary
    smart00220
    Location:52 → 312
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:58 → 312
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    108883993..108915525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91604.1 GenPept UniProtKB/Swiss-Prot:Q91604

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials