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RHOH ras homolog family member H [ Homo sapiens (human) ]

Gene ID: 399, updated on 4-Jun-2023

Summary

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Official Symbol
RHOHprovided by HGNC
Official Full Name
ras homolog family member Hprovided by HGNC
Primary source
HGNC:HGNC:686
See related
Ensembl:ENSG00000168421 MIM:602037; AllianceGenome:HGNC:686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTF; ARHH
Summary
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]
Expression
Biased expression in lymph node (RPKM 20.2), bone marrow (RPKM 10.8) and 8 other tissues See more
Orthologs
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Genomic context

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See RHOH in Genome Data Viewer
Location:
4p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (40191080..40246967)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (40161181..40217041)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (40192700..40248587)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NEDD4 binding protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40140819-40141412 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:40149211-40149992 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:40239787-40240778 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:40252200-40253399 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:40259652-40260430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Expression Difference of RhoH Gene in Leukemia and Its Clinical Significance]. Ni J, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2019 Jun. PMID 31204928
  2. An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration. Tajadura-Ortega V, et al. BMC Biol, 2018 Mar 6. PMID 29510700, Free PMC Article
  3. Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells. Oda H, et al. Immunol Lett, 2013 Mar. PMID 23499578
  4. RhoH modulates pre-TCR and TCR signalling by regulating LCK. Wang H, et al. Cell Signal, 2011 Jan. PMID 20851766
  5. RhoH plays distinct roles in T-cell migrations induced by different doses of SDF1 alpha. Wang H, et al. Cell Signal, 2010 Jul. PMID 20184954

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis.
    Title: Weighted gene co-expression network analysis identifies RHOH and TRAF1 as key candidate genes for psoriatic arthritis.
  2. In AML, RhoH expression negatively correlates with recurrence rate, which can be used as a prognostic indicator independently
    Title: [Expression Difference of RhoH Gene in Leukemia and Its Clinical Significance].
  3. RhoH promotes prostate cancer cell migration and RhoH expression levels correlate with prostate cancer progression.
    Title: An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration.
  4. extracellular microenvironment signals regulate RhoH and Kaiso to modulate actin-cytoskeleton structure and transcriptional activity during T cell migration
    Title: RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells.
  5. These results highlight a novel negative regulatory role for RhoH in eosinophil differentiation, most likely in consequence of altered GATA-2 levels.
    Title: RhoH is a negative regulator of eosinophilopoiesis.
  6. Mutations in hematopoiesis-specific Rho GTPases Rac2 and RhoH lead to a wide range of human blood disorders. (Review)
    Title: Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders.
  7. Our current results indicate differential requirements for RhoH in the development of TCRalphabeta CD8alphaalpha IELs compared to other subsets of T cells including agonist selected T cells.
    Title: Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells.
  8. RHOH deficiency leads to T cell defects and persistent epidermodysplasia verruciformis-HPV infections.
    Title: Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.
  9. conclude that RhoH expression provides a key molecular determinant that allows T cells to switch between sensing chemokine-mediated go signals and TCR-dependent stop signals
    Title: Opposing roles for RhoH GTPase during T-cell migration and activation.
  10. RhoH plays a critical role in prosurvival chronic lymphocytic leukemia cell-cell and cell-microenvironment interactions with this agent.
    Title: RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Epidermodysplasia verruciformis, susceptibility to, 4
MedGen: C4749042 OMIM: 618307 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies two new risk loci for Graves' disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39798

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GTPase inhibitor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables small GTPase binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in mast cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in immunological synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
rho-related GTP-binding protein RhoH
Names
GTP-binding protein TTF
TTF, translocation three four
ras homolog gene family, member H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033255.2 RefSeqGene

    Range
    11021..60957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_736

mRNA and Protein(s)

  1. NM_001278359.2 → NP_001265288.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BX413967, DA815617, DA906265
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  2. NM_001278360.2 → NP_001265289.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BX413967, DA906265, DB119883
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000514774.1, ENST00000515503.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  3. NM_001278361.2 → NP_001265290.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon and contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BX413967, DA383563, DA906265
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000514771.1, ENST00000513894.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  4. NM_001278362.2 → NP_001265291.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon and contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BX413967, DA906265, DA950405
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000514773.1, ENST00000515718.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  5. NM_001278363.2 → NP_001265292.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon and uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BI908453, BX413967, DA906265
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000478248.1, ENST00000614836.2
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  6. NM_001278364.2 → NP_001265293.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265293.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' most exons in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BM457874, BX413967, DA906265
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000422241.2, ENST00000508513.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  7. NM_001278365.2 → NP_001265294.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' most exons and lacks an exon in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BI818548, BX413967, DA906265, DA951252
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000514769.1, ENST00000503754.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  8. NM_001278366.2 → NP_001265295.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265295.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' most exons and lacks an exon in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, AW402442, BC014261, BX413967, DA906265
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000514770.1, ENST00000511967.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  9. NM_001278367.2 → NP_001265296.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265296.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains an alternate 5' exon and lacks two exons in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BI818548, BX413967
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000423384.2, ENST00000507851.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  10. NM_001278368.2 → NP_001265297.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains an alternate 5' exon and lacks two exons in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BX413967, DB115332
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000425010.1, ENST00000505618.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  11. NM_001278369.2 → NP_001265298.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_001265298.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an alternate 5' exon and lacks two exons in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BU934664, BX413967
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000426439.2, ENST00000503941.6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  12. NM_004310.5 → NP_004301.1  rho-related GTP-binding protein RhoH precursor

    See identical proteins and their annotated locations for NP_004301.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' UTR, compared to variant 1. Variants 1 through 12 encode the same protein.
    Source sequence(s)
    AA767445, AC095057, BC014261, BX413967, DA906265
    Consensus CDS
    CCDS3458.1
    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Related
    ENSP00000371219.4, ENST00000381799.10
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    40191080..40246967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415674.1 → XP_047271630.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8

  2. XM_011513692.2 → XP_011511994.1  rho-related GTP-binding protein RhoH isoform X1

    See identical proteins and their annotated locations for XP_011511994.1

    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  3. XM_017008189.2 → XP_016863678.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8, Q6ICP4
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  4. XM_047415675.1 → XP_047271631.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    40161181..40217041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349983.1 → XP_054205958.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8

  2. XM_054349981.1 → XP_054205956.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8

  3. XM_054349982.1 → XP_054205957.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q15669
    UniProtKB/TrEMBL
    A0A024R9S8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15669.1 GenPept UniProtKB/Swiss-Prot:Q15669

Gene LinkOut

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