UQCR-C2 Ubiquinol-cytochrome c reductase core protein 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: UQCR-C2provided by FlyBase
Official Full Name: Ubiquinol-cytochrome c reductase core protein 2provided by FlyBase
Primary source: FLYBASE:FBgn0250814
Locus tag: Dmel_CG4169
See related: AllianceGenome:FB:FBgn0250814
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey245; BEST:GH10978; CG 4169; CG4169; Dmel\CG4169; dUQCRC2; UCR2; UQCR-cp2; UQCRC2
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of respiratory chain complex III. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and somatic trunk mesoderm derivative. Used to study chromosome 16p12.1 deletion syndrome. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16584124..16586111)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16577224..16579211)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex III	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex III	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex III	ISS Inferred from Sequence or Structural Similarity more info
part_of respiratory chain complex III	NAS Non-traceable Author Statement more info	PubMed

Names: BEST:GH10978; CG4169-PA; CG4169-PB; UQCR-C2-PA; UQCR-C2-PB; Ubiquinol-cytochrome C reductase complex core protein 2; Ubiquinol-cytochrome c oxidoreductase core protein 2; ubiquinol-cytochrome c reductase

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The following sections contain reference sequences that belong to a specific genome build. Explain