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actb.L actin, beta L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398459, updated on 5-Sep-2025
Official Symbol
actb.L
Official Full Name
actin, beta L homeolog
Primary source
Xenbase:XB-GENE-866011
Locus tag
XELAEV_18045052mg
See related
EnsemblRapid:ENSXLAG00005023468 AllianceGenome:Xenbase:XB-GENE-866011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
actb; g-actin
Summary
Predicted to enable ATP binding activity and hydrolase activity. Predicted to be located in several cellular components, including actin cytoskeleton; dense body; and focal adhesion. Is expressed in cardiovascular system and dermal system. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1 and thrombocytopenia. Orthologous to human ACTB (actin beta). [provided by Alliance of Genome Resources, Jul 2025]
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See actb.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (95175513..95180154, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (84596277..84600960, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family D (Hsp60) member 1 L homeolog Neighboring gene heat shock protein family E (Hsp10) member 1 L homeolog Neighboring gene uncharacterized LOC108701500 Neighboring gene trinucleotide repeat containing 18 L homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium. Bement WM, et al. Nat Cell Biol, 2015 Nov. PMID 26479320, Free PMC Article
  2. Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Miyamoto K, et al. Genes Dev, 2011 May 1. PMID 21536734, Free PMC Article
  3. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Miyashita R, et al. Elife, 2023 Feb 3. PMID 36734974, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
    Title: Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC52661, MGC85343

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dense body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
actin, cytoplasmic 1
Names
beta-actin
cytoplasmic beta-actin

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088953.2 → NP_001082422.1  actin, cytoplasmic 1

    See identical proteins and their annotated locations for NP_001082422.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084121
    UniProtKB/Swiss-Prot
    O93400, P53506, Q5XHD7
    UniProtKB/TrEMBL
    A0A974C008, A0ABE4LL59
    Related
    ENSXLAP00005069417.1, ENSXLAT00005070951.1
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 375
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    95175513..95180154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O93400.1 GenPept UniProtKB/Swiss-Prot:O93400

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials