ror2.L receptor tyrosine kinase like orphan receptor 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ror2.L
Official Full Name: receptor tyrosine kinase like orphan receptor 2 L homeolog
Primary source: Xenbase:XB-GENE-866069
Locus tag: XELAEV_18007002mg
See related: EnsemblRapid:ENSXLAG00005028244
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ror2; xror2
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Genomic context

Location:: chromosome: 1L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (150010743..150102791, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (137133920..137226643, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the Xenopus embryo, Ptk7 functionally interacts with Ror2 to regulate protocadherin papc expression and morphogenesis.
Title: The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2, which require Wnt5a/Ror2 signaling for their dedifferentiation accompanied by changes in cell morphology.
Title: Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine.
Data show that PAPC signaling via RhoA and Wnt5a/Ror2 activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Title: PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus.
Transcriptional regulation of XPAPC by XWnt-5A requires the receptor tyrosine kinase Ror2.
Title: Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway.
demonstrated that this anti-canonical Wnt activity of Del1 is dependent on the Ror2 pathway, which is activated by the non-canonical Wnt ligands
Title: Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior region determination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor tyrosine kinase like orphan receptor 2 L homeolog

Names: receptor tyrosine kinase Xror2

NP_001082312.1

EC 2.7.10.1

XP_018093562.1

EC 2.7.10.1

XP_018093717.1

EC 2.7.10.1

XP_041428210.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088843.1 → NP_001082312.1 receptor tyrosine kinase like orphan receptor 2 L homeolog precursor

See identical proteins and their annotated locations for NP_001082312.1

Status: PROVISIONAL

Source sequence(s)

AB087137

UniProtKB/TrEMBL

A0A974E0Q3, Q8AV69

Related

ENSXLAP00005084652.1, ENSXLAT00005086304.1

Conserved Domains (6) summary

cd00096
Location:77 → 145

Ig; Immunoglobulin domain

cd07468
Location:168 → 305

CRD_TK_ROR2; Cysteine-rich domain of tyrosine kinase-like orphan receptor 2

smart00130
Location:310 → 390

KR; Kringle domain

pfam07679
Location:62 → 150

I-set; Immunoglobulin I-set domain

pfam07714
Location:470 → 743

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:463 → 746

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

150010743..150102791 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018238228.2 → XP_018093717.1 receptor tyrosine kinase like orphan receptor 2 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J0TZ80

Related

ENSXLAP00005084899.1, ENSXLAT00005086561.1
XM_018238073.2 → XP_018093562.1 receptor tyrosine kinase like orphan receptor 2 L homeolog isoform X1

UniProtKB/TrEMBL

A0A8J0U053

Related

ENSXLAP00005084834.1, ENSXLAT00005086495.1
XM_041572276.1 → XP_041428210.1 receptor tyrosine kinase like orphan receptor 2 L homeolog isoform X3

UniProtKB/TrEMBL

A0A8J1LHR0

Related

ENSXLAP00005084461.1, ENSXLAT00005086110.1

Conserved Domains (4) summary

smart00130
Location:278 → 358

KR; Kringle domain

smart00409
Location:36 → 118

IG; Immunoglobulin

cl02447
Location:136 → 273

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

cl21453
Location:431 → 714

PKc_like; Protein Kinases, catalytic domain