vangl2.L VANGL planar cell polarity protein 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: vangl2.L
Official Full Name: VANGL planar cell polarity protein 2 L homeolog
Primary source: Xenbase:XB-GENE-6251797
Locus tag: XELAEV_18040638mg
See related: EnsemblRapid:ENSXLAG00005032875
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: lpp1; ltap; stb1; stbm; vang; stbm1; stbm-a; vangl2; vangl2a; vangl2-a; vangl2-b; Xstrabismus
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Genomic context

Location:: chromosome: 8L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (127333192..127388557, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (112198549..112254297, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate.
Title: Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate.
Asymmetrical enrichment of Vangl2 in individual gut endoderm cells orients polarity and adhesion during radial rearrangements, coordinating digestive epithelial morphogenesis and lumen formation with gut tube elongation.
Title: Vangl2 coordinates cell rearrangements during gut elongation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, calcium modulating pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of plasma membrane protein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vang-like protein 2-A

Names: Van Gogh; protein strabismus-A; strabismus; van Gogh-like protein 2-A; van gogh-like2; vang-like 2 (van gogh, Drosophila) a; vang-like 2 a; xstbm-A; xstrabismus-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088710.1 → NP_001082179.1 vang-like protein 2-A

See identical proteins and their annotated locations for NP_001082179.1

Status: PROVISIONAL

Source sequence(s)

BC072119

UniProtKB/Swiss-Prot

Q90X64

UniProtKB/TrEMBL

A0A974CA55

Related

ENSXLAP00005098455.1, ENSXLAT00005100277.1

Conserved Domains (1) summary

pfam06638
Location:20 → 521

Strabismus; Strabismus protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

127333192..127388557 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)