igf2.S insulin like growth factor 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: igf2.S
Official Full Name: insulin like growth factor 2 S homeolog
Primary source: Xenbase:XB-GENE-6251806
Locus tag: XELAEV_18024355mg
See related: EnsemblRapid:ENSXLAG00005006151 AllianceGenome:Xenbase:XB-GENE-6251806
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: igf2; igf-2; IGF-II; igf2-a; igf2-b; insigf; pp9974
Summary: Enables growth factor activity. Acts upstream of or within head morphogenesis and nervous system development. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 4S

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (7555210..7594180, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (7386199..7425474, complement)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within head morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2.S; insulin-like growth factor II-A

Names: IGF-II-A; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor 2-A; xIGF-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088659.1 → NP_001082128.1 insulin-like growth factor 2.S precursor

See identical proteins and their annotated locations for NP_001082128.1

Status: PROVISIONAL

Source sequence(s)

AY050645

UniProtKB/Swiss-Prot

Q6NS08, Q90WW4

UniProtKB/TrEMBL

A0A974CXU2

Related

ENSXLAP00005018373.1, ENSXLAT00005018672.1

Conserved Domains (2) summary

cd04368
Location:59 → 123

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam08365
Location:150 → 205

IGF2_C; Insulin-like growth factor II E-peptide