incenp.L inner centromere protein L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: incenp.L
Official Full Name: inner centromere protein L homeolog
Primary source: Xenbase:XB-GENE-6251940
Locus tag: XELAEV_18021990mg
See related: EnsemblRapid:ENSXLAG00005020369 AllianceGenome:Xenbase:XB-GENE-6251940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: incenp; incenp-a; incenp-b; xl-incenp
Summary: Enables protein kinase binding activity. Acts upstream of or within spindle assembly. Located in chromosome. Part of chromosome passenger complex. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Jul 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4L

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (15639912..15655220)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (15119354..15134686)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of the Xenopus Aurora B-INCENP structure coordinated by an ATP analogue.
Title: Structure of Aurora B-INCENP in complex with barasertib reveals a potential transinhibitory mechanism.
It was shown that translation of incenp during oocyte maturation appears to be part of oocyte cytoplasmic maturation, preparing the egg for the rapid mitosis following fertilization.
Title: Translation of incenp during oocyte maturation is required for embryonic development in Xenopus laevis.
Incenp and Aurora B exhibit dynamic turnover at centromeres, which is prevented by the anti-Incenp antibody
Title: Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres.
the Aurora B chromosome passenger protein complex, including INCENP and survivin, is regulated during oocyte maturation in Xenopus laevis
Title: Regulation of the Aurora B chromosome passenger protein complex during oocyte maturation in Xenopus laevis.
Data report the crystal structure of Aurora B in complex with the IN-box segment of the inner centromere protein (INCENP) activator and with the small molecule inhibitor Hesperadin.
Title: Mechanism of Aurora B activation by INCENP and inhibition by hesperadin.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: inner centromere protein A

Names: inner centromere protein antigens 135/155kDa; mitotic phosphoprotein 130; xINC; xIncenp

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088421.1 → NP_001081890.1 inner centromere protein A

See identical proteins and their annotated locations for NP_001081890.1

Status: PROVISIONAL

Source sequence(s)

U95094

UniProtKB/Swiss-Prot

O13024, Q4V878, Q7ZXJ9

UniProtKB/TrEMBL

A0A974HN79

Conserved Domains (3) summary

pfam03941
Location:787 → 838

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:5 → 40

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

pfam15346
Location:595 → 734

ARGLU; Arginine and glutamate-rich 1