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zp2.L zzona pellucida glycoprotein 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398089, updated on 16-Jun-2026
Official Symbol
zp2.L
Official Full Name
zzona pellucida glycoprotein 2 L homeolog
Primary source
Xenbase:XB-GENE-976178
Locus tag
XELAEV_18045344mg
See related
EnsemblRapid:ENSXLAG00005019655 AllianceGenome:Xenbase:XB-GENE-976178
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ZPA; zp2; xZP2; xlZPA; gp69/64
Summary
Predicted to act upstream of or within single fertilization. Predicted to be located in egg coat; extracellular region; and plasma membrane. Orthologous to human ZP2 (zona pellucida glycoprotein 2). [provided by Alliance of Genome Resources, Jul 2025]
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See zp2.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
18
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (111728242..111747203)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (101128220..101147219)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene crystallin mu L homeolog Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B L homeolog Neighboring gene melanin-concentrating hormone receptor 1, gene 2 L homeolog Neighboring gene lipid droplet assembly factor 1 L homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Xenopus laevis sperm receptor gp69/64 glycoprotein is a homolog of the mammalian sperm receptor ZP2. Tian J, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927653, Free PMC Article
  2. ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Nishio S, et al. Cell, 2024 Mar 14. PMID 38490181, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Preferred Names
zzona pellucida glycoprotein 2 L homeolog
Names
vitelline envelope 69/64 kDa glycoprotein
zona pellucida glycoprotein 2 (sperm receptor) L homeolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088389.1 → NP_001081858.1  zzona pellucida glycoprotein 2 L homeolog precursor

    See identical proteins and their annotated locations for NP_001081858.1

    Status: PROVISIONAL

    Source sequence(s)
    BC130044
    UniProtKB/TrEMBL
    A0A8J0PRX9, A1L3D9, O73735
    Related
    ENSXLAP00005057714.1, ENSXLAT00005059068.1
    Conserved Domains (2) summary
    smart00241
    Location:351 → 614
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:478 → 613
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    111728242..111747203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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