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prph2.S peripherin 2 (retinal degeneration, slow) S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 398002, updated on 5-Sep-2025
Official Symbol
prph2.S
Official Full Name
peripherin 2 (retinal degeneration, slow) S homeolog
Primary source
Xenbase:XB-GENE-17339014
Locus tag
XELAEV_18028715mg
See related
EnsemblRapid:ENSXLAG00005002560 AllianceGenome:Xenbase:XB-GENE-17339014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
rds; avmd; aofmd; cacd2; prph2; rds38; prph-2; prph2b; tspan22
Summary
Predicted to act upstream of or within cell adhesion and visual perception. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). [provided by Alliance of Genome Resources, Jul 2025]
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See prph2.S in Genome Data Viewer
Location:
chromosome: 5S
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (17923666..17931255, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (17969014..17976603, complement)

Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene BRD4 interacting chromatin remodelling complex associated protein like S homeolog Neighboring gene transcriptional regulating factor 1 S homeolog Neighboring gene ubiquitin protein ligase E3 component n-recognin 2 S homeolog Neighboring gene UTP25, small subunit processor component S homeolog Neighboring gene synaptotagmin 14 S homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification and cellular localization in Xenopus laevis photoreceptors of three Peripherin-2 family members, Prph2, Rom1 and Gp2l, which arose from gene duplication events in the common ancestors of jawed vertebrates. Tam BM, et al. Exp Eye Res, 2024 Feb. PMID 38158174
  2. Three homologs of rds/peripherin in Xenopus laevis photoreceptors that exhibit covalent and non-covalent interactions. Kedzierski W, et al. J Cell Sci, 1996 Oct. PMID 8923216
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and cellular localization in Xenopus laevis photoreceptors of three Peripherin-2 family members, Prph2, Rom1 and Gp2l, which arose from gene duplication events in the common ancestors of jawed vertebrates.
    Title: Identification and cellular localization in Xenopus laevis photoreceptors of three Peripherin-2 family members, Prph2, Rom1 and Gp2l, which arose from gene duplication events in the common ancestors of jawed vertebrates.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC84151, MGC197222, MGC197225

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
peripherin-2
Names
peripherin 2 (retinal degeneration, slow) b
rds/peripherin
retinal degeneration slow protein
xRDS38

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088226.1 → NP_001081695.1  peripherin-2

    See identical proteins and their annotated locations for NP_001081695.1

    Status: PROVISIONAL

    Source sequence(s)
    L79915
    UniProtKB/Swiss-Prot
    O42583
    UniProtKB/TrEMBL
    A0A974CQY2, Q8UUU5
    Related
    ENSXLAP00005007615.1, ENSXLAT00005007738.1
    Conserved Domains (2) summary
    cd03162
    Location:120 → 262
    peripherin_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:20 → 281
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    17923666..17931255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O42583.1 GenPept UniProtKB/Swiss-Prot:O42583

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials