thra.L thyroid hormone receptor alpha L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: thra.L
Official Full Name: thyroid hormone receptor alpha L homeolog
Primary source: Xenbase:XB-GENE-5966552
Locus tag: XELAEV_18043152mg
See related: EnsemblRapid:ENSXLAG00005036592
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: erba; thra; thra1; c-erba; thra-A; TRalpha; nr1a1-A
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (1863574..1951134, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (1807906..1914774, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Furthermore, molecular and transgenic studies have shown that unliganded TRalpha accomplishes these via the recruitment of histone deacetylase (HDAC)-containing corepressor complexes to repress the expression of TH-inducible genes
Title: Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor α.
regions of the Xenopus and mouse Klf9 genes 5-6 kb upstream of the transcription start sites that supported synergistic transactivation by TH plus GC.
Title: Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module.
Type 2 iodothyronine deiodinase activity is required for the death of thyroid hormone receptor (TRalpha)-transfected tail muscle cells induced by a low level of thyroid hormone.
Title: Regulation of thyroid hormone sensitivity by differential expression of the thyroid hormone receptor during Xenopus metamorphosis.
T(3) acts to induce cell proliferation in the tadpole brain predominantly, if not exclusively, via TRalpha.
Title: Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis.
PRMT1 functions transiently as a coactivator in thyroid hormone (T3) receptor (TR)-mediated transcription by enhancing TR-T3 response element binding and further suggest that PRMT1 has tissue-specific roles in regulating the rate of metamorphosis.
Title: Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis.
Binding of liganded thyroid hormnone receptor to the target promoter is reduced when arginine methyltransferase 1 was overexpressed, accompanied by a slight reduction in histone methylation.
Title: Contrasting effects of two alternative splicing forms of coactivator-associated arginine methyltransferase 1 on thyroid hormone receptor-mediated transcription in Xenopus laevis.
investigated the role of steroid receptor coactivator 3 (SRC3) in gene activation by thyroid hormone receptor (TR) in vivo during development
Title: Tissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development.
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 complexes by unliganded thyroid hormone receptors in transcriptional repression during vertebrate development.
Title: Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development.
Data show that thyroid hormone receptors directly mediate the developmental effects of thyroid hormone in individual organs by regulating target gene expression in these organs.
Title: Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosis.
one mechanism for tissue- and gene-specific regulation of TR target gene expression is through tissue and developmental stage-dependent regulation of TR levels
Title: Gene-specific changes in promoter occupancy by thyroid hormone receptor during frog metamorphosis. Implications for developmental gene regulation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear thyroid hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables thyroid hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyroid hormone receptor alpha-A

Names: TRalphaA; nuclear receptor subfamily 1 group A member 1-A; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog); xenTR-alpha1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

1863574..1951134 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018234145.2 → XP_018089634.1 thyroid hormone receptor alpha-A isoform X2

UniProtKB/Swiss-Prot

P18115, Q91911

UniProtKB/TrEMBL

A0A8J0TQR7

Related

ENSXLAP00005109534.1, ENSXLAT00005111736.1
XM_018234144.2 → XP_018089633.1 thyroid hormone receptor alpha-A isoform X1

UniProtKB/Swiss-Prot

B7ZR78, P15204, P18114, P18115, Q91911

UniProtKB/TrEMBL

A0A974BW62

Related

ENSXLAP00005109535.1, ENSXLAT00005111737.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001088126.1: Suppressed sequence

Description

NM_001088126.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.