bmp1.L bone morphogenetic protein 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: bmp1.L
Official Full Name: bone morphogenetic protein 1 L homeolog
Primary source: Xenbase:XB-GENE-6252324
Locus tag: XELAEV_18018758mg
See related: EnsemblRapid:ENSXLAG00005003659 AllianceGenome:Xenbase:XB-GENE-6252324
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: tld; bmp1; xtld; bmp-1; bmp1b; xbmp1; bmp1-a; bmp1-b; bmp1.S; tolloid
Summary: Predicted to enable calcium ion binding activity; metalloendopeptidase activity; and zinc ion binding activity. Predicted to act upstream of or within proteolysis. Is expressed in mesoderm. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1). [provided by Alliance of Genome Resources, Mar 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3L

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (138011767..138069009)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (122453491..122510963)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tsukushi regulates Xnr2, FGF and BMP signaling in Xenopus germ layer formation
Title: Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: bone morphogenetic protein 1 L homeolog

Names: bone morphogenetic protein 1 S homeolog; bone morphogenetic protein 1b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088030.1 → NP_001081499.1 bone morphogenetic protein 1 L homeolog precursor

See identical proteins and their annotated locations for NP_001081499.1

Status: PROVISIONAL

Source sequence(s)

BC080382

UniProtKB/TrEMBL

A0A974DFT4, O57381, Q66KI3

Related

ENSXLAP00005010889.1, ENSXLAT00005011063.1

Conserved Domains (4) summary

cd04281
Location:111 → 310

ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...

pfam00431
Location:425 → 534

CUB; CUB domain

pfam01400
Location:118 → 311

Astacin; Astacin (Peptidase family M12A)

pfam14670
Location:545 → 577

FXa_inhibition; Coagulation Factor Xa inhibitory site