hdac1.L histone deacetylase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hdac1.L
Official Full Name: histone deacetylase 1 L homeolog
Primary source: Xenbase:XB-GENE-6252325
Locus tag: XELAEV_18012537mg
See related: EnsemblRapid:ENSXLAG00005002812 AllianceGenome:Xenbase:XB-GENE-6252325
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: HD1; HDM; ab21; rpd3; gon-10; hdac1a; rpd3l1; hdac1-a; hdac1-b
Summary: Predicted to enable histone deacetylase activity and histone decrotonylase activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Is expressed in ectoderm; mesoderm; nervous system; and visual system. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Jun 2025]
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Genomic context

Location:: chromosome: 2L

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (89715561..89730118, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (84172159..84186813, complement)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 HDAC1) to down-regulate bone morphogenetic protein (BMP) signaling output and reduce id3 protein expression.
Title: The Proto-oncogene Transcription Factor Ets1 Regulates Neural Crest Development through Histone Deacetylase 1 to Mediate Output of Bone Morphogenetic Protein Signaling.
Specific knockdown of HDAC1 by a morpholino (HDAC1-MO) decreased the number of BrdU- and BLBP-labeled cells and increased the acetylation level of histone H4 at lysine 12.
Title: HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone decrotonylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein decrotonylase activity	IEA Inferred from Electronic Annotation more info
enables protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable histone deacetylase 1-A

Names: HD1-A; histone deacetylase 1 a; maternally-expressed histone deacetylase; protein deacetylase HDAC1-A; protein decrotonylase HDAC1-A; yeast RPD3 homologue

NP_001081491.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088022.1 → NP_001081491.1 probable histone deacetylase 1-A

See identical proteins and their annotated locations for NP_001081491.1

Status: PROVISIONAL

Source sequence(s)

BC081136

UniProtKB/Swiss-Prot

O42227, Q66IY9, Q91695

UniProtKB/TrEMBL

A0A974DMV1

Related

ENSXLAP00005008716.1, ENSXLAT00005008842.1

Conserved Domains (1) summary

cd10010
Location:6 → 374

HDAC1; Histone deacetylase 1 (HDAC1)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

89715561..89730118 complement

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GenBank, FASTA, Sequence Viewer (Graphics)