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acvr2b.S activin A receptor type 2B S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397859, updated on 5-Sep-2025
Official Symbol
acvr2b.S
Official Full Name
activin A receptor type 2B S homeolog
Primary source
Xenbase:XB-GENE-17330678
Locus tag
XELAEV_18032808mg
See related
EnsemblRapid:ENSXLAG00005034187 AllianceGenome:Xenbase:XB-GENE-17330678
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
XAR1; xstk2; actriib; actr-iib
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to act upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in visceral heterotaxy 4. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2025]
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See acvr2b.S in Genome Data Viewer
Location:
chromosome: 6S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (8207600..8300526, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (7813240..7906542, complement)

Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 48 S homeolog Neighboring gene sodium channel, voltage gated, type V alpha subunit S homeolog Neighboring gene uncharacterized LOC121394991 Neighboring gene chromosome 6 C9orf152 homolog S homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A carboxyl-terminal truncated version of the activin receptor mediates activin signals in early Xenopus embryos. Nishimatsu S, et al. FEBS Lett, 1992 Nov 9. PMID 1330691
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC80923

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within developmental process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
activin A receptor type 2B S homeolog
Names
activin receptor
activin type IIB receptor
NP_001081479.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088010.1 → NP_001081479.1  activin A receptor type 2B S homeolog precursor

    See identical proteins and their annotated locations for NP_001081479.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077946
    UniProtKB/TrEMBL
    Q9PSL8, Q9PSL9
    Related
    ENSXLAP00005102138.1, ENSXLAT00005104129.1
    Conserved Domains (3) summary
    cd14140
    Location:192 → 482
    STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
    pfam00069
    Location:196 → 469
    Pkinase; Protein kinase domain
    pfam01064
    Location:40 → 118
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    8207600..8300526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials