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plcb3.L phospholipase C beta 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397692, updated on 4-Jan-2025

Summary

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Official Symbol
plcb3.L
Official Full Name
phospholipase C beta 3 L homeolog
Primary source
Xenbase:XB-GENE-1008416
Locus tag
XELAEV_18022208mg
See related
EnsemblRapid:ENSXLAG00005018879 AllianceGenome:Xenbase:XB-GENE-1008416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
plc1; plcb3; plc-xb
Summary
Predicted to enable calcium ion binding activity and phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to human PLCB3 (phospholipase C beta 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See plcb3.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
34
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (26272239..26383232, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (110547484..110550584)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (24749115..24859844, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene uncharacterized XB5994047 L homeolog Neighboring gene sodium/calcium exchanger 1 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B L homeolog Neighboring gene FKBP prolyl isomerase 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. Ma HW, et al. J Biol Chem, 1993 Sep 25. PMID 8397190
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase C beta 3 L homeolog
Names
phospholipase C beta type
phospholipase C, beta 3 (phosphatidylinositol-specific)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087700.2 → NP_001081169.2  phospholipase C beta 3 L homeolog

    Status: VALIDATED

    Source sequence(s)
    JAGEVR010000047
    UniProtKB/TrEMBL
    A0A1L8GJS2, A0A974D3V3, Q92137
    Related
    ENSXLAP00005055832.1, ENSXLAT00005057062.1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    26272239..26383232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041589175.1 → XP_041445109.1  phospholipase C beta 3 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MTE4, Q92137
    Related
    ENSXLAP00005055809.1, ENSXLAT00005057038.1
    Conserved Domains (5) summary
    cd00275
    Location:692 → 809
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:295 → 658
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:13 → 128
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16210
    Location:133 → 283
    EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
    pfam17380
    Location:906 → 1141
    DUF5401; Family of unknown function (DUF5401)
Nucleotide Protein Strain
Heading Accession and Version

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