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PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A [ Sus scrofa (pig) ]

Gene ID: 397610, updated on 5-Sep-2025
Official Symbol
PPP1R14Aprovided by VGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 14Aprovided by VGNC
Primary source
VGNC:VGNC:98539
See related
Ensembl:ENSSSCG00000038077 RGD:14088029
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
CPI17
Expression
Broad expression in lung (RPKM 29.6), mixtures (RPKM 10.5) and 8 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See PPP1R14A in Genome Data Viewer
Location:
chromosome: 6
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (47167105..47174299, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (42669944..42674708, complement)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene signal induced proliferation associated 1 like 3 Neighboring gene uncharacterized LOC110260981 Neighboring gene double PHD fingers 1 Neighboring gene serine peptidase inhibitor, Kunitz type 2 Neighboring gene uncharacterized LOC102167359 Neighboring gene chromosome 6 C19orf33 homolog

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue. Ohki Sy, et al. J Mol Biol, 2003 Mar 7. PMID 12595264
  2. Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation. Ohki S, et al. J Mol Biol, 2001 Dec 7. PMID 11734001
  3. Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa. Hayashi Y, et al. J Biol Chem, 2001 Oct 26. PMID 11517233
  4. Tonic and phasic smooth muscle contraction is not regulated by the PKCα - CPI-17 pathway in swine stomach antrum and fundus. Zhang Y, et al. PLoS One, 2013. PMID 24058600, Free PMC Article
  5. Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor. Eto M, et al. Structure, 2007 Dec. PMID 18073109, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 in intact smooth muscle tissues.
    Title: Tonic and phasic smooth muscle contraction is not regulated by the PKCα - CPI-17 pathway in swine stomach antrum and fundus.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein serine/threonine phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
protein phosphatase 1 regulatory subunit 14A
Names
17-kDa PKC-potentiated inhibitory protein of PP1
CPI-17
protein kinase C-potentiated inhibitor protein of 17 kDa

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214337.1 → NP_999502.1  protein phosphatase 1 regulatory subunit 14A

    See identical proteins and their annotated locations for NP_999502.1

    Status: PROVISIONAL

    Source sequence(s)
    AB008376
    UniProtKB/Swiss-Prot
    O18734, Q9TQZ8, Q9TQZ9, Q9TR00, Q9TR01, Q9TR02
    UniProtKB/TrEMBL
    A0A287A3G0
    Related
    ENSSSCP00000078517.1, ENSSSCT00000094828.1
    Conserved Domains (1) summary
    pfam05361
    Location:1 → 128
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    47167105..47174299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021093577.1 → XP_020949236.1  protein phosphatase 1 regulatory subunit 14A isoform X1

    UniProtKB/TrEMBL
    A0A8D0XF34
    Conserved Domains (1) summary
    pfam05361
    Location:1 → 117
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18734.1 GenPept UniProtKB/Swiss-Prot:O18734

Gene LinkOut

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