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CAPNS1 calpain small subunit 1 [ Sus scrofa (pig) ]

Gene ID: 397587, updated on 5-Mar-2024

Summary

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Official Symbol
CAPNS1provided by VGNC
Official Full Name
calpain small subunit 1provided by VGNC
Primary source
VGNC:VGNC:96937
See related
Ensembl:ENSSSCG00000030149
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
CAPN4
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in lung (RPKM 194.5), subcutaneous adipose (RPKM 164.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See CAPNS1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (45511410..45518610)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (40913605..40920805)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene ovo like zinc finger 3 Neighboring gene RNA polymerase II subunit I Neighboring gene tubulin folding cofactor B Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene zinc finger protein 146 Neighboring gene zinc finger protein 565

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor binding. Lin GD, et al. Nat Struct Biol, 1997 Jul. PMID 9228946
  2. A putative Ca2+-binding protein: structure of the light subunit of porcine calpain elucidated by molecular cloning and protein sequence analysis. Sakihama T, et al. Proc Natl Acad Sci U S A, 1985 Sep. PMID 2994060, Free PMC Article
  3. Association of PPARGC1A and CAPNS1 gene polymorphisms and expression with meat quality traits in pigs. Gandolfi G, et al. Meat Sci, 2011 Dec. PMID 21680104
  4. A high resolution physical and RH map of pig chromosome 6q1.2 and comparative analysis with human chromosome 19q13.1. Martins-Wess F, et al. BMC Genomics, 2003 May 13. PMID 12744726, Free PMC Article
  5. A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor. Todd B, et al. J Mol Biol, 2003 Apr 18. PMID 12684003

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polymorphisms in PPARGC1A and CAPNS1 genes may affect meat quality traits.
    Title: Association of PPARGC1A and CAPNS1 gene polymorphisms and expression with meat quality traits in pigs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain small subunit 1
Names
CANP small subunit
CDPS
CSS1
calcium-activated neutral proteinase small subunit
calcium-dependent protease small subunit 1
calpain I light subunit
calpain regulatory subunit
NP_999483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214318.2 → NP_999483.1  calpain small subunit 1

    See identical proteins and their annotated locations for NP_999483.1

    Status: PROVISIONAL

    Source sequence(s)
    M11779
    UniProtKB/Swiss-Prot
    P04574, Q8SPJ8
    UniProtKB/TrEMBL
    A0A480VEK3, A0A5S6GT88
    Related
    ENSSSCP00000025968.3, ENSSSCT00000031590.4
    Conserved Domains (1) summary
    cl08302
    Location:142 → 192
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    45511410..45518610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04574.1 GenPept UniProtKB/Swiss-Prot:P04574

Gene LinkOut

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