OAS1 2'-5'-oligoadenylate synthetase 1 [Sus scrofa (pig)] - Gene

Summary

Gene symbol: OAS1
Gene description: 2'-5'-oligoadenylate synthetase 1
See related: RGD:13982803
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in lung (RPKM 121.1), subcutaneous adipose (RPKM 83.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: chromosome: 14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	14	NC_010456.5 (38851083..38867427, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	14	NC_010456.4 (41260747..41268627)

Chromosome 14 - NC_010456.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in OAS1.
Title: Identification of SNPs and INDELS in swine transcribed sequences using short oligonucleotide microarrays.
The active sites of OAS and CCA class I enzymes are highly conserved.
Title: 2'-5' oligoadenylate synthetase shares active site architecture with the archaeal CCA-adding enzyme.

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General gene information

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Markers

MARC_66631-66632:1195488232:1 (e-PCR)
- UniSTS:508260

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 2'-5'-oligoadenylate synthetase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of viral genome replication	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of ribonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase 1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1

Names: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase; 2-5A synthase 1; 2-5A synthetase 1; p42 OAS

XP_020929339.1

EC 2.7.7.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214303.2 → NP_999468.2 2'-5'-oligoadenylate synthase 1

Status: PROVISIONAL

Source sequence(s)

AY550259

UniProtKB/TrEMBL

A0A385XJ80, Q5MX78

Conserved Domains (2) summary

cd05400
Location:22 → 207

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:160 → 345

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010456.5 Reference Sscrofa11.1 Primary Assembly

Range

38851083..38867427 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021073680.1 → XP_020929339.1 LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1

UniProtKB/TrEMBL

A0A4X1TH35

Conserved Domains (2) summary

cd05400
Location:93 → 276

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:229 → 414

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus