U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AMY2 amylase, alpha 2B (pancreatic) [ Sus scrofa (pig) ]

Gene ID: 397397, updated on 26-Jun-2026
Gene symbol
AMY2
Gene description
amylase, alpha 2B (pancreatic)
See related
Ensembl:ENSSSCG00000036331 RGD:14192613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
AMY2B
Expression
Broad expression in longissimus dorsi muscle (RPKM 32.5), psoas major muscle (RPKM 22.3) and 7 other tissues See more
Try the new Gene page
Try the new Transcripts and proteins table
See AMY2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2026_06 current Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1) 4 NC_139386.1 (120390748..120412382, complement)
106 previous assembly Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (115172036..115209749, complement)

Chromosome 4 - NC_139386.1Genomic Context describing neighboring genes Neighboring gene serine-rich coiled-coil domain-containing protein 2 pseudogene Neighboring gene uncharacterized LOC106510214 Neighboring gene U2 spliceosomal RNA Neighboring gene pancreatic alpha-amylase Neighboring gene pancreatic alpha-amylase-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure of a pancreatic alpha-amylase bound to a substrate analogue at 2.03 A resolution. Qian M, et al. Protein Sci, 1997 Nov. PMID 9385631, Free PMC Article
  2. Complete amino acid sequence and location of the five disulfide bridges in porcine pancreatic alpha-amylase. Pasero L, et al. Biochim Biophys Acta, 1986 Jan 30. PMID 3484639
  3. Three dimensional structure of porcine pancreatic alpha-amylase at 2.9 A resolution. Role of calcium in structure and activity. Buisson G, et al. EMBO J, 1987 Dec 20. PMID 3502087, Free PMC Article
  4. Localization of the two free thiol groups in the porcine pancreatic alpha-amylase I sequence. Pasero L, et al. Biochem Biophys Res Commun, 1983 Feb 10. PMID 6188459
  5. The crystal structure of porcine pancreatic alpha-amylase in complex with the microbial inhibitor Tendamistat. Wiegand G, et al. J Mol Biol, 1995 Mar 17. PMID 7897663

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. x-ray crystallographic structure of the pig pancreatic alpha-amylase complexed with rho-nitrophenyl-alpha-D-maltoside-flexibility in the active site
    Title: Crystal structure of the pig pancreatic alpha-amylase complexed with rho-nitrophenyl-alpha-D-maltoside-flexibility in the active site.
  2. X-ray map of a pig pancreatic alpha-amylase crystal soaked (and flash-frozen) with a maltopentaose substrate showed a pattern of electron density corresponding to the binding of oligosaccharides at the active site and at three surface binding sites
    Title: Crystal structure of the pig pancreatic alpha-amylase complexed with malto-oligosaccharides.
  3. X-ray crystallography study of pancreatic alpha-amylase (PPA) explains the mechanism of PPA activation by chloride ions.
    Title: Molecular basis of the effects of chloride ion on the acid-base catalyst in the mechanism of pancreatic alpha-amylase.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha-amylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cation binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pancreatic alpha-amylase
Names
1,4-alpha-D-glucan glucanohydrolase
PA
alpha-amylase
alpha-amylase 2B
NP_001431916.1
NP_001431917.1
NP_001431918.1
NP_001431919.1
NP_999360.2
XP_084877030.1
XP_084877031.1
XP_084877032.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001444987.1 → NP_001431916.1  pancreatic alpha-amylase precursor

    Status: VALIDATED

    Source sequence(s)
    AEMK02000025
    UniProtKB/Swiss-Prot
    P00690, Q9TUE4
    UniProtKB/TrEMBL
    F1S574, I3LAV8

  2. NM_001444988.1 → NP_001431917.1  pancreatic alpha-amylase precursor

    Status: VALIDATED

    Source sequence(s)
    AEMK02000025
    UniProtKB/Swiss-Prot
    P00690, Q9TUE4
    UniProtKB/TrEMBL
    F1S574, I3LAV8

  3. NM_001444989.1 → NP_001431918.1  pancreatic alpha-amylase precursor

    Status: VALIDATED

    Source sequence(s)
    AEMK02000025
    UniProtKB/Swiss-Prot
    P00690, Q9TUE4
    UniProtKB/TrEMBL
    F1S574, I3LAV8

  4. NM_001444990.1 → NP_001431919.1  pancreatic alpha-amylase precursor

    Status: VALIDATED

    Source sequence(s)
    AEMK02000025
    UniProtKB/Swiss-Prot
    P00690, Q9TUE4
    UniProtKB/TrEMBL
    F1S574, I3LAV8

  5. NM_214195.2 → NP_999360.2  pancreatic alpha-amylase precursor

    Status: VALIDATED

    Source sequence(s)
    AEMK02000025
    UniProtKB/Swiss-Prot
    P00690, Q9TUE4
    UniProtKB/TrEMBL
    F1S574, I3LAV8
    Related
    ENSSSCP00000007308.3, ENSSSCT00000007507.5

RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

  1. NC_139386.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

    Range
    120390748..120412382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_085020904.1 → XP_084877030.1  pancreatic alpha-amylase isoform X1

  2. XM_085020905.1 → XP_084877031.1  pancreatic alpha-amylase isoform X1

  3. XM_085020906.1 → XP_084877032.1  pancreatic alpha-amylase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00690.3 GenPept UniProtKB/Swiss-Prot:P00690

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.