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ADRB3 adrenoceptor beta 3 [ Sus scrofa (pig) ]

Gene ID: 397356, updated on 17-Aug-2024

Summary

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Official Symbol
ADRB3provided by VGNC
Official Full Name
adrenoceptor beta 3provided by VGNC
Primary source
VGNC:VGNC:111747
See related
Ensembl:ENSSSCG00000015821
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
BAR3
Expression
Biased expression in spleen (RPKM 7.5), lung (RPKM 3.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See ADRB3 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (48468803..48478370)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 15 NC_010457.4 (55481787..55489921, complement)

Chromosome 15 - NC_010457.5Genomic Context describing neighboring genes Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit Neighboring gene eukaryotic translation initiation factor 4E binding protein 1 Neighboring gene 28S ribosomal protein S36, mitochondrial pseudogene Neighboring gene glutamic-oxaloacetic transaminase 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Celiprolol induces β(3)-adrenoceptors-dependent relaxation in isolated porcine coronary arteries. Abdelkrim MA, et al. Can J Physiol Pharmacol, 2013 Oct. PMID 24144049
  2. An insertion/deletion variant of a thymine base in exon 2 of the porcine beta 3-adrenergic receptor gene associated with loin eye muscle area. Hirose K, et al. Anim Sci J, 2009 Dec. PMID 20163650
  3. The β3-adrenoceptor mediates the inhibitory effects of β-adrenoceptor agonists via the urothelium in pig bladder dome. Masunaga K, et al. Neurourol Urodyn, 2010 Sep. PMID 20151470
  4. Beta-adrenergic receptor subtype transcripts in porcine adipose tissue. McNeel RL, et al. J Anim Sci, 1995 Jul. PMID 7592080
  5. β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes. García-Prieto J, et al. Basic Res Cardiol, 2014 Jul. PMID 24951958

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A single-dose administration of beta3AR agonist before reperfusion decreased infarct size and resulted in a consistent and long-term improvement in cardiac function in mouse model of myocardial ischemia reperfusion injury.
    Title: β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes.
  2. Coronary arteries possess functional beta(3)-adrenoceptors mediating endothelium- and NO-dependent relaxation. Celiprolol exerts a beta(3)-adrenoceptor agonistic activity in this vascular bed.
    Title: Celiprolol induces β(3)-adrenoceptors-dependent relaxation in isolated porcine coronary arteries.
  3. beta(3)-adrenoceptors are involved in mediating inhibitory effects of beta-adrenoceptor agonists on detrusor contractions via the urothelium in pig bladder dome.
    Title: The β3-adrenoceptor mediates the inhibitory effects of β-adrenoceptor agonists via the urothelium in pig bladder dome.
  4. We suggest that ADRB3 polymorphism has the potential to be an important genetic marker for prediction of EMA (eye muscle area)in Duroc pigs.
    Title: An insertion/deletion variant of a thymine base in exon 2 of the porcine beta 3-adrenergic receptor gene associated with loin eye muscle area.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables beta3-adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epinephrine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables norepinephrine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-3 adrenergic receptor
Names
adrenergic, beta-3-, receptor
beta 3 adrenergic receptor
beta-3 adrenoceptor
beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099927.1 → NP_001093397.1  beta-3 adrenergic receptor

    See identical proteins and their annotated locations for NP_001093397.1

    Status: PROVISIONAL

    Source sequence(s)
    AB252780
    UniProtKB/Swiss-Prot
    Q95252, Q9MZ00
    UniProtKB/TrEMBL
    A0A8D0NXW0, A0A8J1, A0A8J3
    Related
    ENSSSCP00000016767.3, ENSSSCT00000017229.5
    Conserved Domains (2) summary
    pfam00001
    Location:54 → 346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:54 → 145
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010457.5 Reference Sscrofa11.1 Primary Assembly

    Range
    48468803..48478370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021074691.1 → XP_020930350.1  beta-3 adrenergic receptor isoform X1

    UniProtKB/Swiss-Prot
    Q95252, Q9MZ00
    UniProtKB/TrEMBL
    A0A2C9F3F6
    Conserved Domains (2) summary
    cd14964
    Location:73 → 95
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:51 → 356
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95252.2 GenPept UniProtKB/Swiss-Prot:Q95252

Gene LinkOut

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