IGF1R insulin like growth factor 1 receptor [Sus scrofa (pig)] - Gene

Summary

Official Symbol: IGF1Rprovided by VGNC
Official Full Name: insulin like growth factor 1 receptorprovided by VGNC
Primary source: VGNC:VGNC:109458
See related: Ensembl:ENSSSCG00000030560
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in kidney (RPKM 29.3), lung (RPKM 10.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (137383623..137691038, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (153523944..153853776, complement)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircRNA Profiling of Skeletal Muscle in Two Pig Breeds Reveals CircIGF1R Regulates Myoblast Differentiation via miR-16.
Title: CircRNA Profiling of Skeletal Muscle in Two Pig Breeds Reveals CircIGF1R Regulates Myoblast Differentiation via miR-16.
Porcine IGF-1R synonymous mutations in the intracellular domain affect cell proliferation and alter kinase activity.
Title: Porcine IGF-1R synonymous mutations in the intracellular domain affect cell proliferation and alter kinase activity.
Further study suggested that protegrin-1 activates insulin-like growth factor 1 receptor (IGF1R) and through this receptor it modulates immune activity as well as cell migration.
Title: Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway.
IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Title: Expression of the insulin-like growth factor system in skeletal muscle during embryonic and postnatal development in the first filial generation pigs from Erhualian and Yorkshire reciprocal crosses.
mRNA expression of IGF-I receptor
Title: Developmental changes and the impact of isoflavones on mRNA expression of IGF-I receptor, EGF receptor and related growth factors in porcine skeletal muscle cell cultures.
IGF-1R is expressed in porcine somatostatin-containing islet D-cells
Title: Cell-type specific expression of IGF-1R in porcine islet cells.
This study suggests an association between the affinity of insulin receptors and number of IGF-1 receptors with placental and/or fetal growth.
Title: Placental insulin and insulin-like growth factor I receptors in normal and preeclamptic pregnancies.
IL-1beta impaired the actions of IGF-I at a point distal to the IGF receptor
Title: IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts.

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General gene information

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Markers

Igf1r (e-PCR), detects polymorphism
- UniSTS:526083

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of JNK cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
part_of insulin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 1 receptor

Names: IGF-1 receptor; IGF-I receptor; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor

NP_999337.1

EC 2.7.10.1

XP_020938574.1

EC 2.7.10.1

XP_020938577.1

EC 2.7.10.1

XP_020938579.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214172.1 → NP_999337.1 insulin-like growth factor 1 receptor precursor

See identical proteins and their annotated locations for NP_999337.1

Status: PROVISIONAL

Source sequence(s)

AB003362

UniProtKB/TrEMBL

A0A4X1UKG1, A0A8D0IGG5, A0A8D1VS60, F1CK17

Related

ENSSSCP00000005181.2, ENSSSCT00000005311.6

Conserved Domains (6) summary

cd05032
Location:992 → 1268

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:835 → 924

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:230 → 277

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain

pfam07714
Location:999 → 1266

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010443.5 Reference Sscrofa11.1 Primary Assembly

Range

137383623..137691038 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021082915.1 → XP_020938574.1 insulin-like growth factor 1 receptor isoform X1

UniProtKB/TrEMBL

A0A8D1VS60

Conserved Domains (4) summary

cd05032
Location:993 → 1269

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:836 → 925

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain
XM_021082918.1 → XP_020938577.1 insulin-like growth factor 1 receptor isoform X2

UniProtKB/TrEMBL

A0A8D0IK16

Conserved Domains (4) summary

cd05032
Location:976 → 1252

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:819 → 908

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:158 → 313

Furin-like; Furin-like cysteine rich region

pfam01030
Location:335 → 449

Recep_L_domain; Receptor L domain
XM_021082920.1 → XP_020938579.1 insulin-like growth factor 1 receptor isoform X3

UniProtKB/TrEMBL

A0A8D0IFQ8

Conserved Domains (4) summary

cd05032
Location:856 → 1132

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:699 → 788

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:77 → 193

Furin-like; Furin-like cysteine rich region

pfam01030
Location:215 → 329

Recep_L_domain; Receptor L domain