CPB1 carboxypeptidase B1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CPB1provided by VGNC
Official Full Name: carboxypeptidase B1provided by VGNC
Primary source: VGNC:VGNC:86933
See related: Ensembl:ENSSSCG00000011694 RGD:13892624
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	13	NC_010455.5 (89043822..89088387)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	13	NC_010455.4 (97005130..97030476, complement)

Chromosome 13 - NC_010455.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Its catalytically important Tyr248 residue is oriented and hydrogen-bonded to solvent water molecules, and locates the furthest away from the catalytic zinc ion as compared to previous structures.
Title: Analysis of a new crystal form of procarboxypeptidase B: further insights into the catalytic mechanism.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: carboxypeptidase B

Names: carboxypeptidase B1 (tissue); procarboxypeptidase B

XP_020924199.1

EC 3.4.17.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214169.2 → NP_999334.2 carboxypeptidase B precursor

Status: VALIDATED

Source sequence(s)

AEMK02000089

UniProtKB/Swiss-Prot

P09955, Q9XSP3

UniProtKB/TrEMBL

A0A4X1T166, A0A8D0PCR9, F1SKC7

Related

ENSSSCP00000012464.3, ENSSSCT00000012802.5

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010455.5 Reference Sscrofa11.1 Primary Assembly

Range

89043822..89088387

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021068540.1 → XP_020924199.1 carboxypeptidase B isoform X1

Conserved Domains (2) summary

cd03871
Location:114 → 413

M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup

pfam02244
Location:28 → 104

Propep_M14; Carboxypeptidase activation peptide