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PDX1 pancreatic and duodenal homeobox 1 [ Sus scrofa (pig) ]

Gene ID: 397288, updated on 26-Jun-2026
Official Symbol
PDX1provided by VGNC
Official Full Name
pancreatic and duodenal homeobox 1provided by VGNC
Primary source
VGNC:VGNC:91292
See related
Ensembl:ENSSSCG00000055811 RGD:13872249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
IPF1; PDX-1
Expression
Low expression observed in reference dataset See more
Orthologs
all
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See PDX1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2026_06 current Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1) 11 NC_139393.1 (5941707..5947163)
106 previous assembly Sscrofa11.1 (GCF_000003025.6) 11 NC_010453.5 (5303609..5309063)

Chromosome 11 - NC_139393.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110255797 Neighboring gene ligand of numb-protein X 2 Neighboring gene GS homeobox 1 Neighboring gene microRNA mir-9803 Neighboring gene caudal type homeobox 2 Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Generation of PDX-1 mutant porcine blastocysts by introducing CRISPR/Cas9-system into porcine zygotes via electroporation. Tanihara F, et al. Anim Sci J, 2019 Jan. PMID 30368976
  2. The study of regulatory effects of Pdx-1, MafA and NeuroD1 on the activity of porcine insulin promoter and the expression of human islet amyloid polypeptide. Liu XD, et al. Mol Cell Biochem, 2014 Sep. PMID 24825179
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It is a gene that is crucial for pancreas development during the fetal period and whose monoallelic disruption impairs insulin secretion.
    Title: Generation of PDX-1 mutant porcine blastocysts by introducing CRISPR/Cas9-system into porcine zygotes via electroporation.
  2. Report pancreatic expression of Pdx-1 in pancreas.
    Title: The study of regulatory effects of Pdx-1, MafA and NeuroD1 on the activity of porcine insulin promoter and the expression of human islet amyloid polypeptide.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in type B pancreatic cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pancreas/duodenum homeobox protein 1
Names
homeodomain protein PDX-1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141984.3 → NP_001135456.2  pancreas/duodenum homeobox protein 1

    Status: VALIDATED

    Source sequence(s)
    AEMK02000075
    UniProtKB/TrEMBL
    A0A287B9A1
    Related
    ENSSSCP00000077158.1, ENSSSCT00000105438.1
    Conserved Domains (1) summary
    pfam00046
    Location:150 → 203
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

  1. NC_139393.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

    Range
    5941707..5947163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials