PDX1 pancreatic and duodenal homeobox 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PDX1provided by VGNC
Official Full Name: pancreatic and duodenal homeobox 1provided by VGNC
Primary source: VGNC:VGNC:91292
See related: Ensembl:ENSSSCG00000055811
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: IPF1; PDX-1
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	11	NC_010453.5 (5303609..5309063)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	11	NC_010453.4 (4961177..4966632)

Chromosome 11 - NC_010453.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It is a gene that is crucial for pancreas development during the fetal period and whose monoallelic disruption impairs insulin secretion.
Title: Generation of PDX-1 mutant porcine blastocysts by introducing CRISPR/Cas9-system into porcine zygotes via electroporation.
Report pancreatic expression of Pdx-1 in pancreas.
Title: The study of regulatory effects of Pdx-1, MafA and NeuroD1 on the activity of porcine insulin promoter and the expression of human islet amyloid polypeptide.

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General gene information

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Markers

S0392 (e-PCR), detects polymorphism
- UniSTS:253085

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in type B pancreatic cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pancreas/duodenum homeobox protein 1

Names: homeodomain protein PDX-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001141984.3 → NP_001135456.2 pancreas/duodenum homeobox protein 1

Status: VALIDATED

Source sequence(s)

AEMK02000075

UniProtKB/TrEMBL

A0A287B9A1, A0A4X1TIC3, B6D5I0

Related

ENSSSCP00000077158.1, ENSSSCT00000105438.1

Conserved Domains (1) summary

pfam00046
Location:150 → 203

Homeobox; Homeobox domain