PPARA peroxisome proliferator activated receptor alpha [Sus scrofa (pig)] - Gene

Summary

Official Symbol: PPARAprovided by VGNC
Official Full Name: peroxisome proliferator activated receptor alphaprovided by VGNC
Primary source: VGNC:VGNC:91682
See related: Ensembl:ENSSSCG00000000006
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: PPARALPHA
Annotation information: Annotation category: partial on reference assembly
Expression: Broad expression in liver (RPKM 37.2), kidney (RPKM 28.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	5	NC_010447.5 (3302755..3321091, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	5	NC_010447.4 (470097..488440)

Chromosome 5 - NC_010447.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results provide novel insights into regulation of PPAR expression in ovarian follicles. We observed that FSH increased mRNA and protein expression of all PPARs isoforms, while LH only increased PPAR alpha and gamma. Steroids like progesterone and estradiol increased expression of PPAR alpha and gamma without affecting the beta isoform, while testosterone had no effect on all PPARs expression.
Title: Expression of peroxisome proliferator-activated receptors is regulated by gonadotropins and steroid hormones in in vitro porcine ovarian follicles.
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
Title: Polymorphism in 3' untranslated region of the pig PPARA gene influences its transcript level and is associated with adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
Title: The quantitative expression of peroxisome proliferator activated receptor (PPAR) genes in porcine endometrium through the estrous cycle and early pregnancy.
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
Title: Gender and genetic differences in bladder smooth muscle PPAR mRNA in a porcine model of the metabolic syndrome.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (SSC4p15), PPARA (SSC5p15), ADIPOR1 (SSC10p13) and CREB (SSC15q24)
Title: Cytogenetic mapping of DGAT1, PPARA, ADIPOR1 and CREB genes in the pig.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Title: Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species.
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
Title: The PPAR-alpha activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs.

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General gene information

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Markers

MARC_31581-31582:1045685661:1 (e-PCR)
- UniSTS:269199

PPARA (e-PCR)
- UniSTS:506332

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: peroxisome proliferator-activated receptor alpha

Names: peroxisome proliferative activated receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044526.1 → NP_001037991.1 peroxisome proliferator-activated receptor alpha

See identical proteins and their annotated locations for NP_001037991.1

Status: PROVISIONAL

Source sequence(s)

DQ437887

UniProtKB/TrEMBL

F1SM76, Q1W4T0

Related

ENSSSCP00000000007.5, ENSSSCT00000000007.5

Conserved Domains (2) summary

cd06932
Location:201 → 467

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:101 → 184

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers