U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3 [ Sus scrofa (pig) ]

Gene ID: 397149, updated on 26-Jun-2026
Official Symbol
PRKAG3provided by VGNC
Official Full Name
protein kinase AMP-activated non-catalytic subunit gamma 3provided by VGNC
Primary source
VGNC:VGNC:98221
See related
Ensembl:ENSSSCG00000016200 RGD:14090811
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Biased expression in longissimus dorsi muscle (RPKM 10.9), heart (RPKM 7.4) and 4 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See PRKAG3 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2026_06 current Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1) 15 NC_139397.1 (135200741..135212610, complement)
106 previous assembly Sscrofa11.1 (GCF_000003025.6) 15 NC_010457.5 (120859486..120866308, complement)

Chromosome 15 - NC_139397.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC146396145 Neighboring gene tubulin tyrosine ligase like 4 Neighboring gene cytochrome P450 family 27 subfamily A member 1 Neighboring gene Wnt family member 6 Neighboring gene Wnt family member 10A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation. Scheffler TL, et al. Physiol Rep, 2016 Jun. PMID 27302990, Free PMC Article
  2. Net lactate accumulation and low buffering capacity explain low ultimate pH in the longissimus lumborum of AMPKγ3 R200Q mutant pigs. Matarneh SK, et al. Meat Sci, 2015 Dec. PMID 26241465
  3. Allelic frequencies of PRKAG3 in several pig breeds and its technological consequences on a Duroc × Landrace-Large White cross. Galve A, et al. J Anim Breed Genet, 2013 Oct. PMID 24074175
  4. The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs. Granlund A, et al. Acta Vet Scand, 2011 Mar 24. PMID 21435205, Free PMC Article
  5. Effects of exercise on muscle glycogen synthesis signalling and enzyme activities in pigs carrying the PRKAG3 mutation. Granlund A, et al. Exp Physiol, 2010 Apr. PMID 20028849

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings indicate that the genetic basis of muscle residual glycogen in swine can be mainly attributed to two major genes PRKAG3 and PHKG1
    Title: Muscle glycogen level and occurrence of acid meat in commercial hybrid pigs are regulated by two low-frequency causal variants with large effects and multiple common variants with small effects.
  2. Activity of glycogen synthase without the allosteric activator glucose 6-phosphate was decreased in gain of function AMPKgamma3(R200Q) relative to all other genotypes
    Title: Gain of function AMP-activated protein kinase γ3 mutation (AMPKγ3R200Q) in pig muscle increases glycogen storage regardless of AMPK activation.
  3. Greater net lactate accumulation postmortem (i.e., glycolytic flux) coupled with a lower buffering capacity explains the lower ultimate pH of meat from AMPKgamma3(R200Q) mutant pigs.
    Title: Net lactate accumulation and low buffering capacity explain low ultimate pH in the longissimus lumborum of AMPKγ3 R200Q mutant pigs.
  4. allelic frequencies of PRKAG3 in several pig breeds
    Title: Allelic frequencies of PRKAG3 in several pig breeds and its technological consequences on a Duroc × Landrace-Large White cross.
  5. The variation in the promoter region of the porcine PRKAG3 gene has associations with meat quality phenotypes, including traits which are influenced by glycolytic potential and muscle metabolism in a breed-dependent manner.
    Title: SNP variation in the promoter of the PRKAG3 gene and association with meat quality traits in pig.
  6. PRKAG3 mutation influences muscle characteristics and promotes an oxidative phenotype to a varying degree among muscles with different functions
    Title: The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs.
  7. increased rate of glycogen synthesis following exercise in pigs carrying the PRKAG3 mutation correlates with an increased signalling response of Akt and its substrate, AS160.
    Title: Effects of exercise on muscle glycogen synthesis signalling and enzyme activities in pigs carrying the PRKAG3 mutation.
  8. the R225Q mutation of PRKAG3 is associated with higher basal AMPK activity and diminished AMP dependence
    Title: The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle.
  9. Genetic variation of PRKAG3 was studied in indigenous breeds of China.
    Title: Genetic variations of the porcine PRKAG3 gene in Chinese indigenous pig breeds.
  10. findings suggest that the R200Q mutation results in a constitutively active enzyme, leading to hyperaccumulation of glycogen due to the increased influx of glucose
    Title: UDP-glucose pyrophosphorylase is upregulated in carriers of the porcine RN- mutation in the AMP-activated protein kinase.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables AMP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of nucleotide-activated protein kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
5'-AMP-activated protein kinase subunit gamma-3
Names
AMP-activated protein kinase gamma subunit
AMPK gamma3
AMPK subunit gamma-3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214077.1 → NP_999242.1  5'-AMP-activated protein kinase subunit gamma-3

    See identical proteins and their annotated locations for NP_999242.1

    Status: PROVISIONAL

    Source sequence(s)
    AF214520
    UniProtKB/Swiss-Prot
    Q53ZT5, Q6WZ89, Q9MYP4
    UniProtKB/TrEMBL
    K7GM96
    Related
    ENSSSCP00000028985.3, ENSSSCT00000033825.4
    Conserved Domains (3) summary
    COG0517
    Location:382 → 499
    CBS; CBS domain [Signal transduction mechanisms]
    cd04618
    Location:226 → 355
    CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    cd04641
    Location:382 → 501
    CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

  1. NC_139397.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

    Range
    135200741..135212610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_084998309.1 → XP_084854435.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X15

  2. XM_084998304.1 → XP_084854430.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X11

  3. XM_084998290.1 → XP_084854416.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X3

  4. XM_084998288.1 → XP_084854414.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X1

  5. XM_084998296.1 → XP_084854422.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X6

  6. XM_084998289.1 → XP_084854415.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X2

  7. XM_084998305.1 → XP_084854431.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X11

  8. XM_084998292.1 → XP_084854418.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X3

  9. XM_084998310.1 → XP_084854436.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X16

  10. XM_084998311.1 → XP_084854437.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X17

  11. XM_084998307.1 → XP_084854433.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X13

  12. XM_084998308.1 → XP_084854434.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X14

  13. XM_084998298.1 → XP_084854424.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X8

  14. XM_084998300.1 → XP_084854426.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X9

  15. XM_084998303.1 → XP_084854429.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X10

  16. XM_084998306.1 → XP_084854432.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X12

  17. XM_084998293.1 → XP_084854419.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X4

  18. XM_084998294.1 → XP_084854420.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X5

  19. XM_084998297.1 → XP_084854423.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X7

  20. XM_084998299.1 → XP_084854425.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X8

  21. XM_084998301.1 → XP_084854427.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X9

  22. XM_084998302.1 → XP_084854428.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X9

  23. XM_084998295.1 → XP_084854421.1  5'-AMP-activated protein kinase subunit gamma-3 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MYP4.2 GenPept UniProtKB/Swiss-Prot:Q9MYP4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials