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IL1A interleukin 1 alpha [ Sus scrofa (pig) ]

Gene ID: 397094, updated on 26-Jun-2026
Official Symbol
IL1Aprovided by VGNC
Official Full Name
interleukin 1 alphaprovided by VGNC
Primary source
VGNC:VGNC:89091
See related
Ensembl:ENSSSCG00000008090 RGD:14209343
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
IL-1alpha
Expression
Biased expression in lung (RPKM 1.8), spleen (RPKM 0.9) and 2 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See IL1A in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2026_06 current Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1) 3 NC_139385.1 (55633390..55646654)
106 previous assembly Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (43718320..43731668)

Chromosome 3 - NC_139385.1Genomic Context describing neighboring genes Neighboring gene interleukin 1, beta 2 Neighboring gene interleukin 1 beta Neighboring gene cytoskeleton associated protein 2 like Neighboring gene 5'-nucleotidase domain containing 4

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Linkage maps of porcine chromosomes 3, 6, and 9 based on 31 polymorphic markers. Johansson M, et al. Mamm Genome, 1994 Dec. PMID 7894160
  2. Porcine IL-1 alpha cDNA nucleotide sequence. Maliszewski CR, et al. Nucleic Acids Res, 1990 Jul 25. PMID 2377484, Free PMC Article
  3. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Lee W, et al. Proc Natl Acad Sci U S A, 2021 Mar 30. PMID 33758095, Free PMC Article
  4. Constitutive repression of interleukin-1alpha in endothelial cells. Brunn GJ, et al. Circ Res, 2008 Apr 11. PMID 18292602, Free PMC Article
  5. Mapping of the regulatory type I alpha and catalytic beta subunits of cAMP-dependent protein kinase and interleukin 1 alpha and 1 beta in the pig. Mellink C, et al. Mamm Genome, 1994 May. PMID 8075502

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of immature T cell proliferation in thymus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-1 alpha
Names
IL-1 alpha

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214029.1 → NP_999194.1  interleukin-1 alpha precursor

    See identical proteins and their annotated locations for NP_999194.1

    Status: PROVISIONAL

    Source sequence(s)
    X52731
    UniProtKB/Swiss-Prot
    P18430
    Related
    ENSSSCP00000008638.1, ENSSSCT00000008863.3
    Conserved Domains (2) summary
    smart00125
    Location:129 → 266
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1 → 107
    IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

  1. NC_139385.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

    Range
    55633390..55646654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013987857.3 → XP_013843311.1  interleukin-1 alpha isoform X2

    Related
    ENSSSCP00000065513.1
    Conserved Domains (2) summary
    smart00125
    Location:82 → 219
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1 → 60
    IL1_propep; Interleukin-1 propeptide

  2. XM_005655198.4 → XP_005655255.1  interleukin-1 alpha isoform X1

    See identical proteins and their annotated locations for XP_005655255.1

    UniProtKB/Swiss-Prot
    P18430
    Conserved Domains (2) summary
    smart00125
    Location:129 → 266
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1 → 107
    IL1_propep; Interleukin-1 propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18430.1 GenPept UniProtKB/Swiss-Prot:P18430

Gene LinkOut

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