OXCT1 3-oxoacid CoA-transferase 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: OXCT1provided by VGNC
Official Full Name: 3-oxoacid CoA-transferase 1provided by VGNC
Primary source: VGNC:VGNC:91113
See related: Ensembl:ENSSSCG00000016863 RGD:13954900
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: OXCT; SCOT
Expression: Broad expression in heart (RPKM 203.4), subcutaneous adipose (RPKM 149.8) and 7 other tissues See more
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	16	NC_010458.4 (26514497..26659739, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	16	NC_010458.3 (27840670..27923998, complement) , (27702633..27729489, complement)

Chromosome 16 - NC_010458.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mechanism of SCOT catalysis
Title: Catalytic role of the conformational change in succinyl-CoA:3-oxoacid CoA transferase on binding CoA.
On the basis of these results the conformational change in SCOT was deduced to be a domain rotation of 17 degrees coupled with movement of two loops: res. 321-329 that interact with succinate or acetoacetate and res. 374-386 that interact with CoA.
Title: Identification of the cysteine residue exposed by the conformational change in pig heart succinyl-CoA:3-ketoacid coenzyme A transferase on binding coenzyme A.
Structure of the CoA transferase from pig heart to 1.7 A resolution
Title: Structure of the CoA transferase from pig heart to 1.7 A resolution.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in ketone body catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Names: SCOT-s; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinate-coenzyme A transferase; succinyl-CoA:3-oxoacid CoA transferase; succinyl-CoA:alpha-ketoacid coenzyme A transferase

NP_999103.1

EC 2.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.