CMAH cytidine monophospho-N-acetylneuraminic acid hydroxylase [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CMAHprovided by VGNC
Official Full Name: cytidine monophospho-N-acetylneuraminic acid hydroxylaseprovided by VGNC
Primary source: VGNC:VGNC:109137
See related: Ensembl:ENSSSCG00000001099
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Annotation information: Annotation category: partial on reference assembly
Expression: Biased expression in spleen (RPKM 22.6), lung (RPKM 7.8) and 4 other tissues See more
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Genomic context

Location:: chromosome: 7

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (19879367..19917761, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (21032289..21070741, complement)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2.
Title: Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2.
Silencing the GGTA1, CMAH and B4GalNT2 genes in pigs achieved a significant antigen reduction. Changing the porcine carbohydrate profile effectively mediates human antibody-mediated complement dependent cytoxicity.
Title: Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation.
Many waitlisted renal transplant patients have minimal xenoreactive antibody binding to the GGTA1/CMAH/B4GalNT2 knockout pig, but some HLA antibodies in sensitized patients cross-react with class I SLA.
Title: Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs.
Silencing the porcine CMAH/GGTA1 genes necessary to avoid antibody-mediated rejection in a pig-to-human model also reduces the xenogeneic consumption of human platelets by the porcine liver.
Title: Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers.
GGTA1/CMAH knockout pig samples had increased relative amounts of high-mannose, incomplete, and xylosylated N-linked glycans
Title: N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens.
Report cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase from porcine endothelial cells.
Title: A cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase from porcine endothelial cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytidine monophosphate-N-acetylneuraminic acid hydroxylase

Names: CMP-N-acetylneuraminate monooxygenase; CMP-N-acetylneuraminic acid hydroxylase; CMP-Neu5Ac hydroxylase; CMP-NeuAc hydroxylase

NP_001106486.1

EC 1.14.18.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113015.1 → NP_001106486.1 cytidine monophosphate-N-acetylneuraminic acid hydroxylase

See identical proteins and their annotated locations for NP_001106486.1

Status: PROVISIONAL

Source sequence(s)

EU204974

UniProtKB/TrEMBL

A0A8D0I3M8, A0A8D0X7B5, A0A8D1MIW8, A8WAC5, F1RUD5

Related

ENSSSCP00000060314.1, ENSSSCT00000075719.2

Conserved Domains (3) summary

COG2220
Location:135 → 287

UlaG; L-ascorbate metabolism protein UlaG, beta-lactamase superfamily [Carbohydrate transport and metabolism]

cd03473
Location:6 → 112

Rieske_CMP_Neu5Ac_hydrolase_N; Cytidine monophosphate-N-acetylneuraminic acid (CMP Neu5Ac) hydroxylase family, N-terminal Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. CMP Neu5Ac hydroxylase is the key enzyme for the synthesis of ...

cl23716
Location:138 → 207

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain