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LDLR low density lipoprotein receptor [ Sus scrofa (pig) ]

Gene ID: 396801, updated on 1-Mar-2025
Official Symbol
LDLRprovided by VGNC
Official Full Name
low density lipoprotein receptorprovided by VGNC
Primary source
VGNC:VGNC:89671
See related
Ensembl:ENSSSCG00000028512 RGD:13943666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in lung (RPKM 16.8), liver (RPKM 15.8) and 8 other tissues See more
Orthologs
human mouse all
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Try the new Transcripts and proteins table
See LDLR in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (69828348..69864823)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (70193426..70206818, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003541216.1 (2852..14728)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003541283.1 (2108..5876, complement)

Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110259342 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene KN motif and ankyrin repeat domains 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry. Ma Y-X, et al. J Virol, 2024 Jan 23. PMID 38054618, Free PMC Article
  2. Identification of a novel Arg-->Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs. Grunwald KA, et al. J Lipid Res, 1999 Mar. PMID 10064736
  3. Identification of a mutation in the low density lipoprotein receptor gene associated with recessive familial hypercholesterolemia in swine. Hasler-Rapacz J, et al. Am J Med Genet, 1998 Apr 13. PMID 9556295
  4. Mechanisms of regulation of ovarian sterol metabolism by insulin-like growth factor type II: in vitro studies with swine granulosa cells. Garmey JC, et al. Endocrinology, 1993 Aug. PMID 8344216
  5. Nucleotide sequence and association analysis of pig apolipoprotein-B and LDL-receptor genes. Pena RN, et al. Anim Biotechnol, 2009. PMID 19544207

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry.
    Title: Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry.
  2. The LDLR gene should be a candidate causative gene for LDL-cholesterol and total cholesterol in pigs, but heterogeneity exists in different populations.
    Title: Evaluation of the causality of the low-density lipoprotein receptor gene (LDLR) for serum lipids in pigs.
  3. found association between genotypes for LDLR and APOB polymorphisms and serum lipid levels, but none of them seem to be the causal mutation but probably represent closely linked polymorphisms
    Title: Nucleotide sequence and association analysis of pig apolipoprotein-B and LDL-receptor genes.
  4. KLF13 and SREBP-Sp1 activation interact to regulate low density lipoprotein receptor promoter function
    Title: A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
low-density lipoprotein receptor
Names
LDL receptor

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206354.2 → NP_001193283.1  low-density lipoprotein receptor precursor

    See identical proteins and their annotated locations for NP_001193283.1

    Status: VALIDATED

    Source sequence(s)
    AF065990, AK236400, FS668646, S64272
    UniProtKB/TrEMBL
    A0A8D1MT39, W0G5E7
    Related
    ENSSSCP00000021308.2, ENSSSCT00000029210.2
    Conserved Domains (5) summary
    smart00135
    Location:555 → 597
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:356 → 386
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:531 → 571
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:320 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

    Range
    69828348..69864823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021080452.1 → XP_020936111.1  low-density lipoprotein receptor isoform X3

    UniProtKB/TrEMBL
    A0A4X1VIY7, I3LB89
    Related
    ENSSSCP00000030589.3, ENSSSCT00000033970.3
    Conserved Domains (5) summary
    smart00135
    Location:555 → 597
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:356 → 386
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:198 → 233
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:531 → 571
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:320 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_021080457.1 → XP_020936116.1  low-density lipoprotein receptor isoform X4

    UniProtKB/TrEMBL
    A0A5G2Q7C7, A0A8D1D6X6, A0A8D1IN79
    Related
    ENSSSCP00000059974.1, ENSSSCT00000091324.1
    Conserved Domains (5) summary
    smart00135
    Location:492 → 534
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:293 → 323
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:135 → 170
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:468 → 508
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:257 → 291
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_021080444.1 → XP_020936103.1  low-density lipoprotein receptor isoform X1

    UniProtKB/TrEMBL
    A0A8D1BXE2
    Conserved Domains (5) summary
    smart00135
    Location:588 → 630
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:389 → 419
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:231 → 266
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:564 → 604
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:353 → 387
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  4. XM_021080449.1 → XP_020936108.1  low-density lipoprotein receptor isoform X2

    UniProtKB/TrEMBL
    A0A4X1VIZ9, A0A8D1BXE2
    Related
    ENSSSCP00000070721.1, ENSSSCT00000069615.1
    Conserved Domains (5) summary
    smart00135
    Location:588 → 630
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:389 → 419
    EGF_CA; Calcium-binding EGF-like domain
    pfam00057
    Location:231 → 266
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:564 → 604
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:353 → 387
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28832.2 GenPept UniProtKB/Swiss-Prot:Q28832

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