ESR2 estrogen receptor 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: ESR2provided by VGNC
Official Full Name: estrogen receptor 2provided by VGNC
Primary source: VGNC:VGNC:97986
See related: Ensembl:ENSSSCG00000005109 RGD:14195148
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: ER2; ER-beta
Expression: Biased expression in ovary (RPKM 3.1) and kidney (RPKM 0.2) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (193823666..193907330)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (215715909..215788512)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There were no statistical differences between the BB genotype and the AB genotype of ESR2 locus in regard to the examined traits. However, a noticeable superiority (P < 0.01) of the BB genotype compared to the homozygous AA genotype, adding almost 2 piglets/litter in TNB and NBA trait, was found.
Title: Association of BF, RBP4, and ESR2 Genotypes with Litter Size in an Autochthonous Pig Population.
steroid hormones, AhR and estrogen receptor beta are affected by TCDD and genistein in granulosa cells of medium porcine follicles
Title: The combined effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and the phytoestrogen genistein on steroid hormone secretion, AhR and ERβ expression and the incidence of apoptosis in granulosa cells of medium porcine follicles.
Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 and PAR-2) associate with breast cancer outcome in an estrogen receptor (ER)-dependent manner.
Title: Protease Activated Receptors 1 and 2 Correlate Differently with Breast Cancer Aggressiveness Depending on Tumor ER Status.
results might shed new light on the roles of estrogen receptor 2(ESR2) in spermatogenesis as candidate for boar fertility
Title: Investigation on association and expression of ESR2 as a candidate gene for boar sperm quality and fertility.
study is the first one to demonstrate the presence of estrogen receptors alpha and beta in the porcine uterus not only at the beginning but also at mid- and late pregnancy
Title: Expression of oestrogen receptor α and oestrogen receptor β in the uterus of the pregnant swine.
The expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Title: Messenger RNA levels of estrogen receptors alpha and beta and progesterone receptors in the cyclic and inseminated/early pregnant sow uterus.
ESR2 gene polymorphisms are associated with litter size.
Title: Detection of novel single-nucleotide polymorphisms (SNPs) in the CYP21 gene and association analysis of two SNPs for CYP21 and ESR2 with litter size in a commercial sow population.
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
Title: Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
Title: Evidence for estrogen receptor alpha and beta expression in skeletal muscle of pigs.
findings suggest that testicular oestrogen receptors alpha and beta may be important factors contributing to onset and maintenance of spermatogenesis in the boar
Title: Expression of oestrogen receptors alpha and beta and of aromatase in the testis of immature and mature boars.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

BARC0079 (e-PCR)
- UniSTS:277892

SW216 (e-PCR), detects polymorphism
- UniSTS:251878

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: estrogen receptor beta

Names: estrogen receptor 2 (ER beta); nuclear receptor subfamily 3 group A member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001533.1 → NP_001001533.1 estrogen receptor beta

See identical proteins and their annotated locations for NP_001001533.1

Status: PROVISIONAL

Source sequence(s)

AF164957

UniProtKB/Swiss-Prot

Q9BDW5, Q9XSW2

UniProtKB/TrEMBL

A0A4X1WCR1

Conserved Domains (3) summary

cd06949
Location:260 → 494

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:141 → 222

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:16 → 119

ERbeta_N; Estrogen receptor beta

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010443.5 Reference Sscrofa11.1 Primary Assembly

Range

193823666..193907330

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021081294.1 → XP_020936953.1 estrogen receptor beta isoform X1

UniProtKB/TrEMBL

A0A4X1WCR1, A0A8D0RLP1, A0A8D1EPG8, F1SRR6

Conserved Domains (3) summary

cd06949
Location:260 → 494

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:141 → 222

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:12 → 119

ERbeta_N; Estrogen receptor beta
XM_021081350.1 → XP_020937009.1 estrogen receptor beta isoform X1

UniProtKB/TrEMBL

A0A4X1WCR1, A0A8D0RLP1, A0A8D1EPG8, F1SRR6

Conserved Domains (3) summary

cd06949
Location:260 → 494

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:141 → 222

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:12 → 119

ERbeta_N; Estrogen receptor beta
XM_021081392.1 → XP_020937051.1 estrogen receptor beta isoform X1

UniProtKB/TrEMBL

A0A4X1WCR1, A0A8D0RLP1, A0A8D1EPG8, F1SRR6

Related

ENSSSCP00000005491.1, ENSSSCT00000005632.4

Conserved Domains (3) summary

cd06949
Location:260 → 494

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:141 → 222

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:12 → 119

ERbeta_N; Estrogen receptor beta