APOB apolipoprotein B [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: APOBprovided by CGNC
Official Full Name: apolipoprotein Bprovided by CGNC
Primary source: CGNC:12347
See related: Ensembl:ENSGALG00010007977
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (102034902..102070377, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (101798981..101834430, complement)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic heat stress resulted in lipid accumulation in the liver of broilers, which is probably because the limited ApoB was not enough to transport the excessive TG synthesized by the liver in chronic heat-stressed broilers.
Title: Increased fat synthesis and limited apolipoprotein B cause lipid accumulation in the liver of broiler chickens exposed to chronic heat stress.
The expression of the ADFP, FATP1 and APOB genes is associated with the fat traits of Yunnan's top six chicken breeds.
Title: Expression of APOB, ADFP and FATP1 and their correlation with fat deposition in Yunnan's top six famous chicken breeds.
The expression level of apoA I in group 2 (diseased) significantly decreased on d 60; the expression level of apoB100 slightly increased on d 30 in group 2, while it sharply decreased on d 60. Compared to group 1 (control), the expression level of apoB100 showed no significant difference in group 3 (protected).
Title: Abnormal histopathology, fat percent and hepatic apolipoprotein A I and apolipoprotein B100 mRNA expression in fatty liver hemorrhagic syndrome and their improvement by soybean lecithin.
Epistatic effects between ApoB and UCP is associated with abdominal fat trait in chicken.
Title: [Genetic analysis of epistatic effects between ApoB and UCP on abdominal fat trait in chicken].
Results of differential expression showed that the APOB gene was more highly expressed in intestine and kidney in Bai'er layer than in broiler, but there was no significant difference in liver between the two breeds.
Title: Cloning and tissue expression characterization of the chicken APOB gene.
measure the presence and quantity of triacylglycerol in the surface of intact native apolipoprotein B-100-containing lipoprotein particles
Title: Integral apolipoproteins increase surface-located triacylglycerol in intact native apoB-100-containing lipoproteins.
Octanoate reduced VLDL secretion by the specific down-regulation of apoB gene expression and impairment of subsequent synthesis of apoB, not by the modulation of intracellular apoB degradation.
Title: Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytes.
results of the present study suggest a primary function of apoB gene in the chicken and that the use of molecular genetic markers associated with the apoB gene can be used in a selection program for low abdominal fat
Title: Single marker and haplotype analysis of the chicken apolipoprotein B gene T123G and D9500D9- polymorphism reveals association with body growth and obesity.

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General gene information

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Homology

Homologs of the APOB gene: The APOB gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 483 organisms have orthologs with human gene APOB
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chylomicron	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apolipoprotein B

Names: apolipoprotein B (including Ag(x) antigen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044633.2 → NP_001038098.2 apolipoprotein B precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000070

UniProtKB/TrEMBL

A0A8V0XV56

Related

ENSGALP00010010560.1, ENSGALT00010019011.1

Conserved Domains (3) summary

COG0419
Location:2133 → 2529

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

TIGR02169
Location:4116 → 4509

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cl26969
Location:38 → 589

Vitellogenin_N; Lipoprotein amino terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

102034902..102070377 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

101798981..101834430 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)