LGALS1A galectin 1A [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: LGALS1Aprovided by CGNC
Official Full Name: galectin 1Aprovided by CGNC
Primary source: CGNC:49833
See related: Ensembl:ENSGALG00010010935
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CG-1B; LGALS1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (51206395..51209566, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (51503150..51506321, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galectin-1B has anti-Newcastle disease virus activity by binding to N-glycans on hemagglutinin-neuraminidase glycoprotein.
Title: Chicken galectin-1B inhibits Newcastle disease virus adsorption and replication through binding to hemagglutinin-neuraminidase (HN) glycoprotein.
Vertebrates have a highly conserved gene for galectin-1-related protein.It is the sixth protein of this family in chicken, a model for network analysis.It lacks canonical capacity to bind lactose.Its crystal structure explains this loss of activity.
Title: Galectin-related protein: An integral member of the network of chicken galectins 1. From strong sequence conservation of the gene confined to vertebrates to biochemical characteristics of the chicken protein and its crystal structure.
Data indicate that the diffusion constant of avian galectin-1 (CG-1B) increased by 5.6% in the presence of lactose, as has been seen for the human galectin-1.
Title: Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: different structural alterations upon oxidation and ligand binding.
Chicken alectins 1 and galectins 2 promote influenza virus binding in dose dependent manner.
Title: Galectins promote the interaction of influenza virus with its target cell.

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General gene information

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Markers

LGALS4sts3 (e-PCR), detects polymorphism
- UniSTS:280067

MCW0043 (e-PCR), detects polymorphism
- UniSTS:280095

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables laminin binding	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-galactoside-binding lectin

Names: 14 kDa lectin; 14K beta-galactoside-binding lectin; C-14; galectin 1; galectin CG-1B; gbl; lectin, galactoside-binding, soluble, 1 (galectin 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205495.2 → NP_990826.1 beta-galactoside-binding lectin

See identical proteins and their annotated locations for NP_990826.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000012

UniProtKB/Swiss-Prot

P07583

UniProtKB/TrEMBL

A0A8V0Y2H5

Related

ENSGALP00010014816.1, ENSGALT00010026192.1

Conserved Domains (1) summary

smart00276
Location:12 → 135

GLECT; Galectin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

51206395..51209566 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046924539.1 → XP_046780495.1 beta-galactoside-binding lectin isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

51503150..51506321 complement

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GenBank, FASTA, Sequence Viewer (Graphics)