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HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [ Gallus gallus (chicken) ]

Gene ID: 396487, updated on 11-Jun-2025
Official Symbol
HSPA5provided by CGNC
Official Full Name
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)provided by CGNC
Primary source
CGNC:667
See related
Ensembl:ENSGALG00010027969
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
GRP78; Hsc70
Orthologs
human mouse all
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See HSPA5 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (10199762..10203834, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (9610244..9614316, complement)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene protein phosphatase 6 catalytic subunit Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene mitogen-activated protein kinase associated protein 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Membrane-associated GRP78 helps subgroup J avian leucosis virus enter cells. Wang L, et al. Vet Res, 2016 Sep 6. PMID 27599847, Free PMC Article
  2. GRP78 is required for cell proliferation and protection from apoptosis in chicken embryo fibroblast cells. Jeon M, et al. Poult Sci, 2016 May. PMID 26944959
  3. Association analysis between SNPs in the 5'-flanking region of the chicken GRP78 gene, thermotolerance parameters, and tissue mRNA expression. Kong LN, et al. Genet Mol Res, 2015 Jun 10. PMID 26125812
  4. Avian reovirus S1133-induced apoptosis is associated with Bip/GRP79-mediated Bim translocation to the endoplasmic reticulum. Lin PY, et al. Apoptosis, 2015 Apr. PMID 25576194
  5. 78-kilodalton glucose-regulated protein is induced in Rous sarcoma virus-transformed cells independently of glucose deprivation. Stoeckle MY, et al. Mol Cell Biol, 1988 Jul. PMID 2841586, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. helps subgroup J avian leucosis virus enter cells
    Title: Membrane-associated GRP78 helps subgroup J avian leucosis virus enter cells.
  2. These findings have important implications for the maintenance of chicken fibroblast cells through the inhibition of apoptosis and may lead to the development of new treatments for avian disease.
    Title: GRP78 is required for cell proliferation and protection from apoptosis in chicken embryo fibroblast cells.
  3. Data indicate that mRNA expression level of GRP78 gene increased gradually under heat stress then decreased after a certain time suggesting that GRP78 mRNA expression is time- and tissue-dependent.
    Title: Association analysis between SNPs in the 5'-flanking region of the chicken GRP78 gene, thermotolerance parameters, and tissue mRNA expression.
  4. BiP/GRP78 played critical roles and works upstream of JNK-Bim in response to the ARV S1133-mediated apoptosis process.
    Title: Avian reovirus S1133-induced apoptosis is associated with Bip/GRP79-mediated Bim translocation to the endoplasmic reticulum.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables misfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of endoplasmic reticulum chaperone complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
endoplasmic reticulum chaperone BiP
Names
78 kDa glucose-regulated protein
GRP-78
HSP70 family protein 5
biP
binding-immunoglobulin protein
heat shock 70 kDa protein 5
heat shock protein 70 family protein 5
heat shock protein family A member 5
immunoglobulin heavy chain-binding protein
NP_990822.1
XP_040504914.1
XP_046784744.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205491.2 → NP_990822.1  endoplasmic reticulum chaperone BiP precursor

    See identical proteins and their annotated locations for NP_990822.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000308
    UniProtKB/Swiss-Prot
    Q90593
    Related
    ENSGALP00010041529.1, ENSGALT00010067786.1
    Conserved Domains (1) summary
    pfam00012
    Location:28 → 633
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    10199762..10203834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040648980.2 → XP_040504914.1  endoplasmic reticulum chaperone BiP isoform X1

    UniProtKB/Swiss-Prot
    Q90593
    Conserved Domains (1) summary
    pfam00012
    Location:28 → 633
    HSP70; Hsp70 protein

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9610244..9614316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928788.1 → XP_046784744.1  endoplasmic reticulum chaperone BiP isoform X1

    UniProtKB/Swiss-Prot
    Q90593
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90593.1 GenPept UniProtKB/Swiss-Prot:Q90593

Gene LinkOut

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