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NGF nerve growth factor [ Gallus gallus (chicken) ]

Gene ID: 396466, updated on 12-Aug-2018

Summary

Symbol
NGFprovided by CGNC
Full Name
nerve growth factorprovided by CGNC
Primary source
CGNC:1838
See related
Ensembl:ENSGALG00000002556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NGFB; beta-NGF
Orthologs

Genomic context

See NGF in Genome Data Viewer
Location:
chromosome: 26
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCg6a (GCF_000002315.5) 26 NC_006113.5 (4027554..4050532, complement)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 26 NC_006113.4 (4027894..4050872, complement)

Chromosome 26 - NC_006113.5Genomic Context describing neighboring genes Neighboring gene thyroid stimulating hormone beta Neighboring gene tetraspanin 2 Neighboring gene uncharacterized LOC101747848 Neighboring gene uncharacterized LOC101747934 Neighboring gene FA complementation group E

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
beta-nerve growth factor
Names
nerve growth factor (beta polypeptide)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293108.1NP_001280037.1  beta-nerve growth factor precursor

    See identical proteins and their annotated locations for NP_001280037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BU313448, BU337330, CD217960
    UniProtKB/TrEMBL
    A0A140T8F7
    Related
    ENSGALP00000004030.4, ENSGALT00000004039.4
    Conserved Domains (1) summary
    pfam00243
    Location:128236
    NGF; Nerve growth factor family
  2. NM_001293109.1NP_001280038.1  beta-nerve growth factor precursor

    See identical proteins and their annotated locations for NP_001280038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BU313448, BU337330, BU382314
    UniProtKB/TrEMBL
    A0A140T8F7
    Related
    ENSGALP00000047700.1, ENSGALT00000055126.1
    Conserved Domains (1) summary
    pfam00243
    Location:128236
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCg6a Primary Assembly

Genomic

  1. NC_006113.5 Reference GRCg6a Primary Assembly

    Range
    4027554..4050532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025143679.1XP_024999447.1  beta-nerve growth factor isoform X1

    Conserved Domains (1) summary
    pfam00243
    Location:173280
    NGF; Nerve growth factor family
  2. XM_015298897.2XP_015154383.1  beta-nerve growth factor isoform X2

    UniProtKB/TrEMBL
    A0A140T8F7
    Conserved Domains (1) summary
    pfam00243
    Location:128236
    NGF; Nerve growth factor family
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