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LCK LCK proto-oncogene, Src family tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 396460, updated on 17-Aug-2024
Symbol
LCKprovided by CGNC
Full Name
LCK proto-oncogene, Src family tyrosine kinaseprovided by CGNC
Primary source
CGNC:49815
See related
Ensembl:ENSGALG00010017442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
tkl; P56LCK; p56tk1
Orthologs
human mouse all
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See LCK in Genome Data Viewer
Location:
chromosome: 23
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 23 NC_052554.1 (5501337..5507124, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 23 NC_052595.1 (5264732..5270516, complement)

Chromosome 23 - NC_052554.1Genomic Context describing neighboring genes Neighboring gene MARCKS like 1 Neighboring gene histone deacetylase 1 Neighboring gene myotubularin related protein 9 like pseudogene Neighboring gene family with sequence similarity 167 member B Neighboring gene eukaryotic translation initiation factor 3 subunit I Neighboring gene transmembrane protein 234

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene. Chow LM, et al. Mol Cell Biol, 1992 Mar. PMID 1545804, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
proto-oncogene tyrosine-protein kinase LCK
Names
lymphocyte-specific protein tyrosine kinase
protein-tyrosine kinase C-TKL
tyrosine protein kinase
tyrosine-protein kinase LCK
NP_001383615.1
XP_015153340.1
XP_015153341.1
XP_040507732.1
XP_040545781.1
XP_040545782.1
XP_040545783.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396686.1 → NP_001383615.1  proto-oncogene tyrosine-protein kinase LCK

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000339
    UniProtKB/Swiss-Prot
    P42683, Q53WS8
    Conserved Domains (3) summary
    cd10362
    Location:147 → 247
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:89 → 142
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:261 → 524
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5501337..5507124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015297855.4 → XP_015153341.1  proto-oncogene tyrosine-protein kinase LCK isoform X3

    UniProtKB/Swiss-Prot
    P42683, Q53WS8
    Conserved Domains (3) summary
    cd10362
    Location:121 → 221
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:63 → 116
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:235 → 498
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  2. XM_040651798.2 → XP_040507732.1  proto-oncogene tyrosine-protein kinase LCK isoform X1

    UniProtKB/Swiss-Prot
    P42683, Q53WS8
    Conserved Domains (3) summary
    cd10362
    Location:146 → 246
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:88 → 141
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:260 → 523
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  3. XM_015297854.4 → XP_015153340.1  proto-oncogene tyrosine-protein kinase LCK isoform X2

    UniProtKB/Swiss-Prot
    P42683, Q53WS8
    Related
    ENSGALP00010024656.1, ENSGALT00010042110.1
    Conserved Domains (3) summary
    cd10362
    Location:122 → 222
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:64 → 117
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:236 → 499
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052595.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5264732..5270516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040689849.2 → XP_040545783.1  proto-oncogene tyrosine-protein kinase LCK isoform X3

    UniProtKB/Swiss-Prot
    P42683, Q53WS8
    Conserved Domains (3) summary
    cd10362
    Location:121 → 221
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:63 → 116
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:235 → 498
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  2. XM_040689847.2 → XP_040545781.1  proto-oncogene tyrosine-protein kinase LCK isoform X1

    UniProtKB/Swiss-Prot
    P42683, Q53WS8
    Conserved Domains (3) summary
    cd10362
    Location:146 → 246
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:88 → 141
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:260 → 523
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk

  3. XM_040689848.2 → XP_040545782.1  proto-oncogene tyrosine-protein kinase LCK isoform X2

    UniProtKB/Swiss-Prot
    P42683, Q53WS8
    Conserved Domains (3) summary
    cd10362
    Location:122 → 222
    SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
    cd12005
    Location:64 → 117
    SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
    cd05067
    Location:236 → 499
    PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42683.2 GenPept UniProtKB/Swiss-Prot:P42683

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