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RBP riboflavin binding protein [ Gallus gallus (chicken) ]

Gene ID: 396449, updated on 18-Mar-2023

Summary

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Official Symbol
RBPprovided by CGNC
Official Full Name
riboflavin binding proteinprovided by CGNC
Primary source
CGNC:49810
See related
Ensembl:ENSGALG00010026367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Rd; RTBDN
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Genomic context

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See RBP in Genome Data Viewer
Location:
chromosome: 8
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (20930694..20949055, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (20939614..20957971, complement)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 69 Neighboring gene intracisternal A particle-promoted polypeptide Neighboring gene uncharacterized LOC121111449 Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene uncharacterized LOC121111450

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein-cofactor binding and ultrafast electron transfer in riboflavin binding protein under the spatial confinement of nanoscopic reverse micelles. Saha R, et al. J Mol Recognit, 2013 Feb. PMID 23334913
  2. Riboflavin-binding protein exhibits selective sweet suppression toward protein sweeteners. Maehashi K, et al. Chem Senses, 2007 Feb. PMID 17167172
  3. Estrogen regulation of chicken riboflavin carrier protein gene is mediated by ERE half sites without direct binding of estrogen receptor. Bahadur U, et al. Mol Cell Endocrinol, 2005 Feb 28. PMID 15713531
  4. Evaluation of riboflavin binding protein domain interaction using differential scanning calorimetry. Wasylewski M. Biochim Biophys Acta, 2004 Nov 1. PMID 15488765
  5. Riboflavinuria in the rd chicken. 5'-splice site mutation in the gene for riboflavin-binding protein. MacLachlan I, et al. J Biol Chem, 1993 Nov 5. PMID 8226844

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using moxestrol and riboflavin carrier protein promoter/reporter constructs in chicken hepatoma cells, an estrogen response unit (ERU) composed of two consensus ERE 1/2 sites and one non-consensus ERE 1/2 site was identified .
    Title: Estrogen regulation of chicken riboflavin carrier protein gene is mediated by ERE half sites without direct binding of estrogen receptor.
  2. Both the hydration and surface charge of the confining volume is expected to largely determine the biochemical reaction dynamics of the riboflavin-binding protein.
    Title: Protein-cofactor binding and ultrafast electron transfer in riboflavin binding protein under the spatial confinement of nanoscopic reverse micelles.
  3. Phosporylation of RBP occurs on serines in a single tryptic peptide and is necessary for uptake of riboflavin to developing oocytes. Egg white and egg yolk proteins have the same peptides but have minor difference in Phosporylation.
    Title: Highly phosphorylated region of chicken riboflavin-binding protein: chemical characterization and 31P NMR studies.
  4. Data estimate not only the thermostability of both N- and C-terminal domains of riboflavin-binding protein but also the strength of domain interactions.
    Title: Evaluation of riboflavin binding protein domain interaction using differential scanning calorimetry.
  5. The selectivity in the sweet suppression by RBP is consistent with the existence of multiple interaction sites within a single sweet taste receptor.
    Title: Riboflavin-binding protein exhibits selective sweet suppression toward protein sweeteners.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables riboflavin binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables riboflavin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables riboflavin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables riboflavin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sensory perception of sweet taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in riboflavin transport IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
riboflavin-binding protein
Names
retbindin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205463.2 → NP_990794.1  riboflavin-binding protein precursor

    See identical proteins and their annotated locations for NP_990794.1

    Status: VALIDATED

    Source sequence(s)
    BU267624, J03922
    UniProtKB/Swiss-Prot
    P02752
    UniProtKB/TrEMBL
    A0A140T8H8
    Related
    ENSGALP00010039453.1, ENSGALT00010064171.1
    Conserved Domains (1) summary
    pfam03024
    Location:22 → 188
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    20930694..20949055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040704519.2 → XP_040560453.1  riboflavin-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8V1A8A6
    Related
    ENSGALP00010039455.1, ENSGALT00010064175.1

  2. XM_025152771.3 → XP_025008539.1  riboflavin-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A140T8H8
    Conserved Domains (1) summary
    pfam03024
    Location:22 → 188
    Folate_rec; Folate receptor family

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    20939614..20957971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922433.1 → XP_046778389.1  riboflavin-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8V1A8A6

  2. XM_046922434.1 → XP_046778390.1  riboflavin-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A140T8H8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02752.2 GenPept UniProtKB/Swiss-Prot:P02752

Gene LinkOut

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