U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MYLK myosin light chain kinase [ Gallus gallus (chicken) ]

Gene ID: 396445, updated on 3-Dec-2024
Symbol
MYLKprovided by CGNC
Full Name
myosin light chain kinaseprovided by CGNC
Primary source
CGNC:8898
See related
Ensembl:ENSGALG00010018627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
KRP; MLCK
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See MYLK in Genome Data Viewer
Location:
chromosome: 7
Exon count:
35
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (26790204..26982564, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (26705167..26897249, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111255 Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC107053877 Neighboring gene uncharacterized LOC124418128 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene coiled-coil domain containing 14 Neighboring gene kalirin RhoGEF kinase Neighboring gene uncharacterized LOC124418096

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Analysis of the functional coupling between Calmodulin's calcium binding and peptide recognition properties. Mirzoeva S, et al. Biochemistry, 1999 Oct 19. PMID 10529260
  2. Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. Collinge M, et al. Mol Cell Biol, 1992 May. PMID 1373815, Free PMC Article
  3. Molecular cloning of the chicken gizzard telokin gene and cDNA. Yoshikai S, et al. Arch Biochem Biophys, 1992 Dec. PMID 1444462
  4. Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity. Shoemaker MO, et al. J Cell Biol, 1990 Sep. PMID 2202734, Free PMC Article
  5. Regulatory and structural motifs of chicken gizzard myosin light chain kinase. Olson NJ, et al. Proc Natl Acad Sci U S A, 1990 Mar. PMID 2315320, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of nonmuscle and smooth muscle myosin by myosin light chain kinase (MLCK) is required for activation of myosin's ATPase activity.
    Title: Myosin light chain kinase steady-state kinetics: comparison of smooth muscle myosin II and nonmuscle myosin IIB as substrates.
  2. Data suggest that dissociation of MLCK (myosin light chain kinase) from phosphorylated SMM (smooth muscle myosin) is the rate-limiting step in SMM phosphorylation kinetic cycle in smooth muscle.
    Title: Kinetics of myosin light chain kinase activation of smooth muscle myosin in an in vitro model system.
  3. Results from various lines of investigation suggest that the actin binding properties of MLCK play important roles in determining actin cytoskeletal organization in smooth muscle, particularly an oligopeptide based on chicken MLCK (26-41).
    Title: Myosin light chain kinase/actin interaction in phorbol dibutyrate-stimulated smooth muscle cells.
  4. MLCK and calmodulin (CaM) co-purify with unphosphorylated SMM from chicken gizzard, suggesting that they are tightly bound.
    Title: Characterization of tightly associated smooth muscle myosin-myosin light-chain kinase-calmodulin complexes.
  5. Tight junctions serve as attachment points for the actomyosin ring during wound closure and that Rho-kinase is required for localization and activation of the contractile ring.
    Title: Two distinct modes of myosin assembly and dynamics during epithelial wound closure.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables myosin light chain kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tonic smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
myosin light chain kinase, smooth muscle
Names
kinase related protein
myosin, light polypeptide kinase
smooth muscle myosin light chain kinase (61-kDa active fragment)
telokin
NP_001309290.2
NP_990790.3
XP_040559302.1
XP_040559303.1
XP_046777165.1
XP_046777166.1
XP_046777167.1
XP_046777168.1
XP_046799495.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322361.3 → NP_001309290.2  myosin light chain kinase, smooth muscle isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0Z722
    Related
    ENSGALP00010026948.1, ENSGALT00010045114.1
    Conserved Domains (7) summary
    smart00408
    Location:598 → 661
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:91 → 175
    IG; Immunoglobulin
    smart00410
    Location:219 → 302
    IG_like; Immunoglobulin like
    cd00063
    Location:1375 → 1466
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1507 → 1765
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:313 → 482
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cd00096
    Location:230 → 234
    Ig; Ig strand B [structural motif]

  2. NM_205459.4 → NP_990790.3  myosin light chain kinase, smooth muscle isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0Z153, A0A8V0ZEF9
    Related
    ENSGALP00010026943.1, ENSGALT00010045098.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    26790204..26982564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046943539.1 → XP_046799495.1  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z153, A0A8V0ZEF9
    Related
    ENSGALP00010026938.1, ENSGALT00010045091.1

  2. XM_040703368.2 → XP_040559302.1  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z722, A0A8V0Z7L8
    Related
    ENSGALP00010026947.1, ENSGALT00010045109.1
    Conserved Domains (7) summary
    smart00408
    Location:530 → 593
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:219 → 302
    IG; Immunoglobulin
    smart00410
    Location:1084 → 1162
    IG_like; Immunoglobulin like
    cd00063
    Location:1307 → 1398
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1439 → 1697
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:313 → 482
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cd00096
    Location:533 → 540
    Ig; Ig strand B [structural motif]

  3. XM_040703369.1 → XP_040559303.1  myosin light chain kinase, smooth muscle isoform X3

    Conserved Domains (5) summary
    smart00409
    Location:1219 → 1301
    IG; Immunoglobulin
    smart00410
    Location:158 → 239
    IG_like; Immunoglobulin like
    cd00063
    Location:735 → 826
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:867 → 1125
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cd00096
    Location:159 → 164
    Ig; Ig strand A' [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    26705167..26897249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921211.1 → XP_046777167.1  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/Swiss-Prot
    P11799, P19038, Q549S2
    UniProtKB/TrEMBL
    A0A8V0Z153, A0A8V0ZEF9

  2. XM_046921209.1 → XP_046777165.1  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z722

  3. XM_046921210.1 → XP_046777166.1  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/Swiss-Prot
    P11799, P19038, Q549S2
    UniProtKB/TrEMBL
    A0A8V0Z153, A0A8V0ZEF9

  4. XM_046921212.1 → XP_046777168.1  myosin light chain kinase, smooth muscle isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11799.2 GenPept UniProtKB/Swiss-Prot:P11799

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials