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MYLK myosin light chain kinase [ Gallus gallus (chicken) ]

Gene ID: 396445, updated on 3-Apr-2024

Summary

Symbol
MYLKprovided by CGNC
Full Name
myosin light chain kinaseprovided by CGNC
Primary source
CGNC:8898
See related
Ensembl:ENSGALG00010018627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
KRP; MLCK
Orthologs
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Genomic context

See MYLK in Genome Data Viewer
Location:
chromosome: 7
Exon count:
35
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (26790204..26982564, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (26705167..26897249, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111255 Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC107053877 Neighboring gene uncharacterized LOC124418128 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene coiled-coil domain containing 14 Neighboring gene kalirin RhoGEF kinase Neighboring gene uncharacterized LOC124418096

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables myosin light chain kinase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in tonic smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
myosin light chain kinase, smooth muscle
Names
kinase related protein
myosin, light polypeptide kinase
smooth muscle myosin light chain kinase (61-kDa active fragment)
telokin
NP_001309290.2
NP_990790.3
XP_040559302.1
XP_040559303.1
XP_046777165.1
XP_046777166.1
XP_046777167.1
XP_046777168.1
XP_046799495.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322361.3NP_001309290.2  myosin light chain kinase, smooth muscle isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0Z722
    Related
    ENSGALP00010026948.1, ENSGALT00010045114.1
    Conserved Domains (7) summary
    smart00408
    Location:598661
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:91175
    IG; Immunoglobulin
    smart00410
    Location:219302
    IG_like; Immunoglobulin like
    cd00063
    Location:13751466
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:15071765
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:313482
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cd00096
    Location:230234
    Ig; Ig strand B [structural motif]
  2. NM_205459.4NP_990790.3  myosin light chain kinase, smooth muscle isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    Related
    ENSGALP00010026943.1, ENSGALT00010045098.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    26790204..26982564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046943539.1XP_046799495.1  myosin light chain kinase, smooth muscle isoform X2

    Related
    ENSGALP00010026938.1, ENSGALT00010045091.1
  2. XM_040703368.2XP_040559302.1  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z722, A0A8V0Z7L8
    Related
    ENSGALP00010026947.1, ENSGALT00010045109.1
    Conserved Domains (7) summary
    smart00408
    Location:530593
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:219302
    IG; Immunoglobulin
    smart00410
    Location:10841162
    IG_like; Immunoglobulin like
    cd00063
    Location:13071398
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:14391697
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:313482
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cd00096
    Location:533540
    Ig; Ig strand B [structural motif]
  3. XM_040703369.1XP_040559303.1  myosin light chain kinase, smooth muscle isoform X3

    Conserved Domains (5) summary
    smart00409
    Location:12191301
    IG; Immunoglobulin
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:735826
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:8671125
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cd00096
    Location:159164
    Ig; Ig strand A' [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    26705167..26897249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921211.1XP_046777167.1  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/Swiss-Prot
    P11799, P19038, Q549S2
  2. XM_046921209.1XP_046777165.1  myosin light chain kinase, smooth muscle isoform X1

  3. XM_046921210.1XP_046777166.1  myosin light chain kinase, smooth muscle isoform X2

    UniProtKB/Swiss-Prot
    P11799, P19038, Q549S2
  4. XM_046921212.1XP_046777168.1  myosin light chain kinase, smooth muscle isoform X3