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SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 396442, updated on 5-Dec-2021

Summary

Symbol
SRCprovided by CGNC
Full Name
SRC proto-oncogene, non-receptor tyrosine kinaseprovided by CGNC
Primary source
CGNC:49807
See related
Ensembl:ENSGALG00000003855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SDR; c-src; PP60C-SCR
Orthologs
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Genomic context

See SRC in Genome Data Viewer
Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
105 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (5409096..5426620)
105 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.1) 20 NC_052592.1 (5211532..5220682)
104 previous assembly GRCg6a (GCF_000002315.5) 20 NC_006107.5 (5066299..5083801)
103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 20 NC_006107.4 (5212325..5229840)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene growth hormone releasing hormone Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC121107309 Neighboring gene bladder cancer associated protein Neighboring gene phosphatidylinositol glycan anchor biosynthesis class T

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables connexin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoclast development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase Src
Names
c-src protein, C terminus
non-tyrosine protein kinase
p60-Src
pp60c-src
proto-oncogene c-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
XP_015151832.2
XP_015151833.2
XP_015151834.2
XP_040506588.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205457.4NP_990788.4  proto-oncogene tyrosine-protein kinase Src

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5409096..5426620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040650654.1XP_040506588.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:150250
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85146
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:263539
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  2. XM_015296348.3XP_015151834.2  proto-oncogene tyrosine-protein kinase Src isoform X2

    Conserved Domains (3) summary
    cd10365
    Location:144244
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85140
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:257533
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  3. XM_015296346.3XP_015151832.2  proto-oncogene tyrosine-protein kinase Src isoform X1

    Related
    ENSGALP00000006117.3
    Conserved Domains (3) summary
    cd10365
    Location:150250
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85146
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:263539
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
  4. XM_015296347.3XP_015151833.2  proto-oncogene tyrosine-protein kinase Src isoform X1

    Conserved Domains (3) summary
    cd10365
    Location:150250
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85146
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:263539
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5211532..5220682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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