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SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 396442, updated on 19-May-2023

Summary

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Symbol
SRCprovided by CGNC
Full Name
SRC proto-oncogene, non-receptor tyrosine kinaseprovided by CGNC
Primary source
CGNC:49807
See related
Ensembl:ENSGALG00010021638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
SDR; c-src; PP60C-SCR
Orthologs
human mouse all
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Genomic context

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See SRC in Genome Data Viewer
Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 20 NC_052551.1 (5409053..5426622)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 20 NC_052592.1 (5203712..5221226)

Chromosome 20 - NC_052551.1Genomic Context describing neighboring genes Neighboring gene growth hormone releasing hormone Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC121107309 Neighboring gene bladder cancer associated protein Neighboring gene phosphatidylinositol glycan anchor biosynthesis class T Neighboring gene dysbindin domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Host Src controls gallid alpha herpesvirus 1 intercellular spread in a cellular fatty acid metabolism-dependent manner. Wang Z, et al. Virology, 2019 Nov. PMID 31425969, Free PMC Article
  2. Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites. Tong M, et al. Nat Commun, 2017 Dec 18. PMID 29255153, Free PMC Article
  3. Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells. Li H, et al. J Virol, 2016 Jan 1. PMID 26446601, Free PMC Article
  4. Distinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation. Morgan JC, et al. Clin Exp Metastasis, 2005. PMID 16086237
  5. The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions. Williams JC, et al. J Mol Biol, 1997 Dec 19. PMID 9405157

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overall, these data suggest that Src controls the cell-to-cell spread of Infectious laryngotracheitis virus in a cellular fatty acid metabolism-dependent manner, which determines the virus's cytopathic effect.
    Title: Host Src controls gallid alpha herpesvirus 1 intercellular spread in a cellular fatty acid metabolism-dependent manner.
  2. Data indicate a highly conserved amino acid, Gly449, that is necessary for Src kinase activation.
    Title: Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites.
  3. JunD and AP-1 antagonize the induction of DAPK1 to promote the survival of v-Src-transformed cells.
    Title: JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells.
  4. Therefore, Src is essential for viral replication in vitro and in ovo but is not required for infectious laryngotracheitis herpesvirus-induced cell death.
    Title: Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells.
  5. Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion
    Title: Calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion.
  6. Src is expressed in spinal lateral motor neurons of chick embryo at the time of limb trajectory selection.
    Title: SRC family kinases are required for limb trajectory selection by spinal motor axons.
  7. KV11 peptide (from human Apolipoprotein A) suppresses angiogenesis and tumor progression by targeting the c-Src/ERK signaling pathways in VEGF induced cells
    Title: A novel peptide from human apolipoprotein(a) inhibits angiogenesis and tumor growth by targeting c-Src phosphorylation in VEGF-induced human umbilical endothelial cells.
  8. Activation of Src is a key mechanisms by which collagen I provokes capillary morphogenesis of microvascular endothelial cells
    Title: Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells.
  9. Formation of hemangiosarcomas in chick embryo required presence of src SH3 domain and, to some extent, SH2 domain; implicates distinct and opposite roles for SH2 and SH3 domains of src and cellular binding partners in tumorigenesis and hemorrhagic disease
    Title: Distinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation.
  10. protein kinase Src promotes translation by phosphorylating a key tyrosine residue in ZBP1 that is required for binding to RNA
    Title: Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables connexin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in osteoclast development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in progesterone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase Src
Names
c-src protein, C terminus
non-tyrosine protein kinase
p60-Src
pp60c-src
proto-oncogene c-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
NP_990788.4
XP_015151832.2
XP_015151834.2
XP_040506588.1
XP_046758757.1
XP_046786562.1
XP_046786563.1
XP_046786564.1
XP_046786565.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205457.4 → NP_990788.4  proto-oncogene tyrosine-protein kinase Src

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000328
    UniProtKB/Swiss-Prot
    Q98915
    Conserved Domains (3) summary
    cd10365
    Location:144 → 244
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85 → 140
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:257 → 533
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5409053..5426622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046902801.1 → XP_046758757.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q3Z0

  2. XM_040650654.2 → XP_040506588.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q3Z0
    Conserved Domains (3) summary
    cd10365
    Location:150 → 250
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85 → 146
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:263 → 539
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  3. XM_015296348.4 → XP_015151834.2  proto-oncogene tyrosine-protein kinase Src isoform X2

    UniProtKB/Swiss-Prot
    Q98915
    Conserved Domains (3) summary
    cd10365
    Location:144 → 244
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85 → 140
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:257 → 533
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

  4. XM_015296346.4 → XP_015151832.2  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q3Z0
    Related
    ENSGALP00010031467.1, ENSGALT00010052562.1
    Conserved Domains (3) summary
    cd10365
    Location:150 → 250
    SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
    cd12008
    Location:85 → 146
    SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
    cd05071
    Location:263 → 539
    PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052592.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5203712..5221226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046930608.1 → XP_046786564.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q3Z0

  2. XM_046930606.1 → XP_046786562.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q3Z0

  3. XM_046930609.1 → XP_046786565.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    UniProtKB/Swiss-Prot
    Q98915

  4. XM_046930607.1 → XP_046786563.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q3Z0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00523.4 GenPept UniProtKB/Swiss-Prot:P00523

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