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VCL vinculin [ Gallus gallus (chicken) ]

Gene ID: 396422, updated on 23-Nov-2017
Symbol
VCLprovided by CGNC
Full Name
vinculinprovided by CGNC
Primary source
CGNC:3778
See related
Ensembl:ENSGALG00000005079
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
Location:
chromosome: 6
Exon count:
22
Annotation release Status Assembly Chr Location
103 current Gallus_gallus-5.0 (GCF_000002315.4) 6 NC_006093.4 (15392444..15448529, complement)
102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 6 NC_006093.3 (14961415..15014936, complement)

Chromosome 6 - NC_006093.4Genomic Context describing neighboring genes Neighboring gene adenosine kinase Neighboring gene adaptor related protein complex 3 mu 1 subunit Neighboring gene plasminogen activator, urokinase Neighboring gene uncharacterized LOC107053655 Neighboring gene calcium/calmodulin dependent protein kinase II gamma

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystem
    Regulation of Actin Cytoskeleton
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
alpha-actinin binding IDA
Inferred from Direct Assay
more info
PubMed 
alpha-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
muscle alpha-actinin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
vinculin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adherens junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
morphogenesis of an epithelium IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
brush border IDA
Inferred from Direct Assay
more info
PubMed 
cell IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
costamere ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
inner dense plaque of desmosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
muscle tendon junction IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
outer dense plaque of desmosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle myofibril IDA
Inferred from Direct Assay
more info
PubMed 
NOT smooth muscle dense body IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
terminal web IDA
Inferred from Direct Assay
more info
PubMed 
zonula adherens IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
vinculin
Names
metavinculin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205441.1NP_990772.1  vinculin

    See identical proteins and their annotated locations for NP_990772.1

    Status: PROVISIONAL

    Source sequence(s)
    J04126
    UniProtKB/Swiss-Prot
    P12003
    Related
    ENSGALP00000048583.1, ENSGALT00000061988.1
    Conserved Domains (1) summary
    pfam01044
    Location:661066
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Gallus_gallus-5.0 Primary Assembly

Genomic

  1. NC_006093.4 Reference Gallus_gallus-5.0 Primary Assembly

    Range
    15392444..15448529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015288203.1XP_015143689.1  vinculin isoform X4

    UniProtKB/Swiss-Prot
    P12003
    UniProtKB/TrEMBL
    F1NYY0
    Related
    ENSGALP00000008131.5, ENSGALT00000008145.5
    Conserved Domains (1) summary
    pfam01044
    Location:661135
    Vinculin; Vinculin family
  2. XM_015288200.1XP_015143686.1  vinculin isoform X1

    Conserved Domains (1) summary
    pfam01044
    Location:661067
    Vinculin; Vinculin family
  3. XM_015288201.1XP_015143687.1  vinculin isoform X2

    Conserved Domains (1) summary
    pfam01044
    Location:66985
    Vinculin; Vinculin family
  4. XM_015288202.1XP_015143688.1  vinculin isoform X3

    Conserved Domains (1) summary
    pfam01044
    Location:66916
    Vinculin; Vinculin family
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