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TGFBR2 transforming growth factor beta receptor 2 [ Gallus gallus (chicken) ]

Gene ID: 396399, updated on 13-Apr-2026
Official Symbol
TGFBR2provided by CGNC
Official Full Name
transforming growth factor beta receptor 2provided by CGNC
Primary source
CGNC:8694
See related
Ensembl:ENSGALG00010002281
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See TGFBR2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (39709134..39773208)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (39758981..39823066)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109999 Neighboring gene uncharacterized LOC121109998 Neighboring gene RNA binding motif single stranded interacting protein 3 Neighboring gene glutamate decarboxylase like 1 Neighboring gene STT3B, catalytic subunit of the oligosaccharyltransferase complex

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genomic organization, intragenic tandem duplication, and expression analysis of chicken TGFBR2 gene. Ning B, et al. Poult Sci, 2022 Dec. PMID 36201879, Free PMC Article
  2. Solution structure of the chick TGFbeta type II receptor ligand-binding domain. Marlow MS, et al. J Mol Biol, 2003 Feb 28. PMID 12589747
  3. TGF-beta elicits fibronectin secretion and proliferation in cultured chick lens epithelial cells. Richiert DM, et al. Curr Eye Res, 1999 Jan. PMID 10075204
  4. Antibodies to the Type II TGFbeta receptor block cell activation and migration during atrioventricular cushion transformation in the heart. Brown CB, et al. Dev Biol, 1996 Mar 15. PMID 8631497
  5. Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Mercado-Pimentel ME, et al. Cells Tissues Organs, 2007. PMID 17587820

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures
    Title: Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken.
  2. mRNA expression of genes of the TGF beta family and endothelin 1 in lung samples from 4-week-old chickens with pulmonary hypertension, were determined.
    Title: Over, and underexpression of endothelin 1 and TGF-beta family ligands and receptors in lung tissue of broilers with pulmonary hypertension.
  3. Data show that TGF-beta1, -beta2, and -beta3 and their receptors have distinct spatiotemporal developmental protein localization patterns in the developing tendon and suggest that these isoforms have independent roles in tendon development.
    Title: Spatiotemporal protein distribution of TGF-betas, their receptors, and extracellular matrix molecules during embryonic tendon development.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables activin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta receptor activity, type II IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type I transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of signaling receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
TGF-beta receptor type-2
Names
TGF-beta receptor type II
TGF-beta type II receptor
TGFR-2
TGFbeta type II receptor
tbetaR-II
transforming growth factor, beta receptor II (70/80kDa)
transforming growth factor-beta receptor type II
transforming growth factor-beta type II receptor
NP_990759.1
XP_015136807.1
XP_046766440.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205428.2 → NP_990759.1  TGF-beta receptor type-2 precursor

    See identical proteins and their annotated locations for NP_990759.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000037
    UniProtKB/Swiss-Prot
    Q90999
    UniProtKB/TrEMBL
    A0A8V0X4Y5
    Conserved Domains (3) summary
    smart00221
    Location:234 → 524
    STYKc; Protein kinase; unclassified specificity
    cd14055
    Location:239 → 532
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:39 → 140
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    39709134..39773208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015281321.4 → XP_015136807.1  TGF-beta receptor type-2 isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q417, A0A8V0XEK6
    Related
    ENSGALP00010003049.1, ENSGALT00010005177.1
    Conserved Domains (3) summary
    smart00221
    Location:348 → 638
    STYKc; Protein kinase; unclassified specificity
    cd14055
    Location:353 → 646
    STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
    pfam08917
    Location:39 → 140
    ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    39758981..39823066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910484.1 → XP_046766440.1  TGF-beta receptor type-2 isoform X1

    UniProtKB/TrEMBL
    A0A1I7Q417, A0A8V0XEK6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90999.1 GenPept UniProtKB/Swiss-Prot:Q90999

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous