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MAP2K2 mitogen-activated protein kinase kinase 2 [ Gallus gallus (chicken) ]

Gene ID: 396349, updated on 19-May-2023

Summary

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Symbol
MAP2K2provided by CGNC
Full Name
mitogen-activated protein kinase kinase 2provided by CGNC
Primary source
CGNC:49765
See related
Ensembl:ENSGALG00010027230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MEK2
Orthologs
human mouse all
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Genomic context

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See MAP2K2 in Genome Data Viewer
Location:
chromosome: 28
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 28 NC_052559.1 (3047760..3057397)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 28 NC_052600.1 (2613950..2623545)

Chromosome 28 - NC_052559.1Genomic Context describing neighboring genes Neighboring gene sirtuin 6 Neighboring gene cAMP responsive element binding protein 3 like 3 Neighboring gene uncharacterized LOC112530431 Neighboring gene C2 calcium dependent domain containing 4C Neighboring gene SHC (Src homology 2 domain containing) transforming protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of cDNAs encoding chicken mitogen-activated protein kinase kinase type 2, MEK2: downregulation of MEK2 in response to inhibition of mitochondrial DNA expression. Wang H, et al. Biochemistry, 1997 Dec 9. PMID 9398267
  2. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 2
Names
ERK activator kinase 2
MAP kinase kinase 2
MAPK/ERK kinase 2
MAPKK 2
mitogen-activated protein kinase kinase type 2
NP_990719.2
XP_015155404.1
XP_046789648.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205388.2 → NP_990719.2  dual specificity mitogen-activated protein kinase kinase 2

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000375
    Related
    ENSGALP00010040281.1, ENSGALT00010066015.1
    Conserved Domains (1) summary
    cd06649
    Location:64 → 394
    PKc_MEK2; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3047760..3057397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015299918.4 → XP_015155404.1  dual specificity mitogen-activated protein kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AAM3
    Related
    ENSGALP00010040282.1, ENSGALT00010066016.1
    Conserved Domains (2) summary
    smart00220
    Location:70 → 362
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:64 → 404
    PKc_like; Protein Kinases, catalytic domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2613950..2623545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046933692.1 → XP_046789648.1  dual specificity mitogen-activated protein kinase kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1AAM3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90891.1 GenPept UniProtKB/Swiss-Prot:Q90891

Gene LinkOut

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