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CTSB cathepsin B [ Gallus gallus (chicken) ]

Gene ID: 396329, updated on 13-Apr-2026
Official Symbol
CTSBprovided by CGNC
Official Full Name
cathepsin Bprovided by CGNC
Primary source
CGNC:12486
See related
Ensembl:ENSGALG00010011386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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See CTSB in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (107170946..107181190, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (106934146..106944366, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene nei like DNA glycosylase 2 Neighboring gene farnesyl-diphosphate farnesyltransferase 1 Neighboring gene microRNA 6690 Neighboring gene microRNA 6702 Neighboring gene avian beta-defensin 13

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Extracellular-matrix degradation at acid pH. Avian osteoclast acid collagenase isolation and characterization. Blair HC, et al. Biochem J, 1993 Mar 15. PMID 8457215, Free PMC Article
  2. Avian cathepsin B cDNA: sequence and demonstration that mRNAs of two sizes are produced in cell types producing large quantities of the enzyme. Dong SS, et al. Biochim Biophys Acta, 1995 Aug 16. PMID 7647095
  3. Lysosomal cathepsins in embryonic programmed cell death. Zuzarte-Luis V, et al. Dev Biol, 2007 Jan 1. PMID 16987511
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cathepsin B
Names
cathepsin B-like enzyme
cathepsin B1
NP_990702.3
XP_046769247.1
XP_046769248.1
XP_046769249.1
XP_046794512.1
XP_046794513.1
XP_046794514.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205371.3 → NP_990702.3  cathepsin B precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000070
    UniProtKB/Swiss-Prot
    P43233
    Related
    ENSGALP00010015504.1, ENSGALT00010027232.1
    Conserved Domains (1) summary
    cd02620
    Location:81 → 329
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    107170946..107181190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938556.1 → XP_046794512.1  cathepsin B isoform X1

    UniProtKB/Swiss-Prot
    P43233
    Related
    ENSGALP00010015515.1, ENSGALT00010027247.1

  2. XM_046938557.1 → XP_046794513.1  cathepsin B isoform X1

    UniProtKB/Swiss-Prot
    P43233

  3. XM_046938558.1 → XP_046794514.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y4G2, A0A8V0YAP2
    Related
    ENSGALP00010015506.1, ENSGALT00010027237.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    106934146..106944366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913291.1 → XP_046769247.1  cathepsin B isoform X1

    UniProtKB/Swiss-Prot
    P43233

  2. XM_046913292.1 → XP_046769248.1  cathepsin B isoform X1

    UniProtKB/Swiss-Prot
    P43233

  3. XM_046913293.1 → XP_046769249.1  cathepsin B isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y4G2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43233.1 GenPept UniProtKB/Swiss-Prot:P43233

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