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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001198714.2 → NP_001185643.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 2
Status: VALIDATED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1.The resulting protein (isoform 2) is the same length but has a distinct N-terminus, compared to isoform 1.
- Source sequence(s)
-
JAENSK010000339
- UniProtKB/Swiss-Prot
-
P35915
- UniProtKB/TrEMBL
-
A0A1L1RJ90
- Related
- ENSGALP00010021543.1, ENSGALT00010037050.1
- Conserved Domains (2) summary
-
- PLN02746
Location:24 → 315
- PLN02746; hydroxymethylglutaryl-CoA lyase
- pfam00682
Location:26 → 300
- HMGL-like; HMGL-like
-
NM_001198715.2 → NP_001185644.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
- Source sequence(s)
-
JAENSK010000339
- UniProtKB/Swiss-Prot
-
P35915
- UniProtKB/TrEMBL
-
A0A8V0YS55
- Related
- ENSGALP00010021547.1, ENSGALT00010037057.1
- Conserved Domains (2) summary
-
- PLN02746
Location:24 → 315
- PLN02746; hydroxymethylglutaryl-CoA lyase
- pfam00682
Location:26 → 300
- HMGL-like; HMGL-like
-
NM_001198716.2 → NP_001185645.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 3
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and four 3' exons, differs in the 3' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
- Source sequence(s)
-
JAENSK010000339
- UniProtKB/TrEMBL
-
A0A1L1S0F6
- Conserved Domains (1) summary
-
- cl21457
Location:23 → 160
- TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
-
NM_001198717.2 → NP_001185646.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 4
Status: VALIDATED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and four 3' exons, uses an alternate splice site in the 5' coding region, differs in the 3' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 4) has a distinct N-terminus and is shorter than isoform 1.
- Source sequence(s)
-
JAENSK010000339
- Conserved Domains (1) summary
-
- cl21457
Location:16 → 138
- TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly
Genomic
-
NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly
- Range
-
5958466..5962095 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_025142964.3 → XP_024998732.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2
- UniProtKB/Swiss-Prot
-
P35915
- Conserved Domains (1) summary
-
- PLN02746
Location:1 → 260
- PLN02746; hydroxymethylglutaryl-CoA lyase
-
XM_025142963.3 → XP_024998731.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1
- UniProtKB/Swiss-Prot
-
P35915
- UniProtKB/TrEMBL
-
A0A8V0YKS1
- Related
- ENSGALP00010021545.1, ENSGALT00010037054.1
- Conserved Domains (1) summary
-
- cd07938
Location:39 → 296
- DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w
Genomic
-
NC_052595.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w
- Range
-
5721762..5725391 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_046931864.1 → XP_046787820.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2
- UniProtKB/Swiss-Prot
-
P35915
-
XM_046931863.1 → XP_046787819.1 hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1
- UniProtKB/Swiss-Prot
-
P35915
- UniProtKB/TrEMBL
-
A0A8V0YKS1