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HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase [ Gallus gallus (chicken) ]

Gene ID: 396316, updated on 19-May-2023

Summary

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Symbol
HMGCLprovided by CGNC
Full Name
3-hydroxy-3-methylglutaryl-CoA lyaseprovided by CGNC
Primary source
CGNC:49749
See related
Ensembl:ENSGALG00010015430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
HL
Orthologs
human mouse all
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Genomic context

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See HMGCL in Genome Data Viewer
Location:
chromosome: 23
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 23 NC_052554.1 (5958466..5962095, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 23 NC_052595.1 (5721762..5725391, complement)

Chromosome 23 - NC_052554.1Genomic Context describing neighboring genes Neighboring gene PITH domain containing 1 Neighboring gene lysophospholipase 2 Neighboring gene UDP-galactose-4-epimerase Neighboring gene alpha-L-fucosidase 1 Neighboring gene cannabinoid receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken. Wang X, et al. Cytogenet Genome Res, 2007. PMID 17675858
  2. 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency. Mitchell GA, et al. J Biol Chem, 1993 Feb 25. PMID 8440722
  3. Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase. Montgomery C, et al. J Biol Chem, 2012 Sep 28. PMID 22865860, Free PMC Article
  4. Conserved BK channel-protein interactions reveal signals relevant to cell death and survival. Sokolowski B, et al. PLoS One, 2011. PMID 22174833, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables hydroxymethylglutaryl-CoA lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydroxymethylglutaryl-CoA lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ketone body biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in ketone body biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leucine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA lyase, mitochondrial
Names
3-hydroxy-3-methylglutarate-CoA lyase
3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMG-CoA lyase
NP_001185643.1
NP_001185644.1
NP_001185645.1
NP_001185646.1
XP_024998731.1
XP_024998732.1
XP_046787819.1
XP_046787820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198714.2 → NP_001185643.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1.The resulting protein (isoform 2) is the same length but has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    JAENSK010000339
    UniProtKB/TrEMBL
    A0A1L1RJ90
    Related
    ENSGALP00010021543.1, ENSGALT00010037050.1
    Conserved Domains (2) summary
    PLN02746
    Location:24 → 315
    PLN02746; hydroxymethylglutaryl-CoA lyase
    pfam00682
    Location:26 → 300
    HMGL-like; HMGL-like

  2. NM_001198715.2 → NP_001185644.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    JAENSK010000339
    UniProtKB/TrEMBL
    A0A8V0YS55, F1P1E7
    Related
    ENSGALP00010021547.1, ENSGALT00010037057.1
    Conserved Domains (2) summary
    PLN02746
    Location:24 → 315
    PLN02746; hydroxymethylglutaryl-CoA lyase
    pfam00682
    Location:26 → 300
    HMGL-like; HMGL-like

  3. NM_001198716.2 → NP_001185645.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and four 3' exons, differs in the 3' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    JAENSK010000339
    UniProtKB/TrEMBL
    A0A1L1S0F6
    Conserved Domains (1) summary
    cl21457
    Location:23 → 160
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

  4. NM_001198717.2 → NP_001185646.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and four 3' exons, uses an alternate splice site in the 5' coding region, differs in the 3' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    JAENSK010000339
    Conserved Domains (1) summary
    cl21457
    Location:16 → 138
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5958466..5962095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025142964.3 → XP_024998732.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02746
    Location:1 → 260
    PLN02746; hydroxymethylglutaryl-CoA lyase

  2. XM_025142963.3 → XP_024998731.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKS1
    Related
    ENSGALP00010021545.1, ENSGALT00010037054.1
    Conserved Domains (1) summary
    cd07938
    Location:39 → 296
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052595.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5721762..5725391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931864.1 → XP_046787820.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2

  2. XM_046931863.1 → XP_046787819.1  hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8V0YKS1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35915.1 GenPept UniProtKB/Swiss-Prot:P35915

Gene LinkOut

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