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IGFBP2 insulin like growth factor binding protein 2 [ Gallus gallus (chicken) ]

Gene ID: 396315, updated on 5-Sep-2025
Symbol
IGFBP2provided by CGNC
Full Name
insulin like growth factor binding protein 2provided by CGNC
Primary source
CGNC:8714
See related
Ensembl:ENSGALG00010019282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
IGFBP-2
Orthologs
human mouse all
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See IGFBP2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (22879236..22951723, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (22799138..22871611, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101750072 Neighboring gene uncharacterized LOC107053888 Neighboring gene insulin like growth factor binding protein 5 Neighboring gene ribosomal protein L37a Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A polymorphism in the 3'-flanking region of insulin-like growth factor binding protein 2 gene associated with abdominal fat in chickens. Leng L, et al. Poult Sci, 2009 May. PMID 19359680
  2. Identification of a single nucleotide polymorphism of the insulin-like growth factor binding protein 2 gene and its association with growth and body composition traits in the chicken. Li ZH, et al. J Anim Sci, 2006 Nov. PMID 17032782
  3. Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2. Schoen TJ, et al. J Mol Endocrinol, 1995 Aug. PMID 8546813
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The research suggests that the IGFBP2 gene could be a candidate locus or linked to a major gene that affects fatness traits in chickens.
    Title: A polymorphism in the 3'-flanking region of insulin-like growth factor binding protein 2 gene associated with abdominal fat in chickens.
  2. The effect of single nucleotide polymorphisms on body composition, body weight, and other traits in chickens are reported.
    Title: Identification of a single nucleotide polymorphism of the insulin-like growth factor binding protein 2 gene and its association with growth and body composition traits in the chicken.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin-like growth factor I binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor II binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
insulin-like growth factor-binding protein 2
Names
IBP-2
IGF binding protein 2
insulin-like growth factor binding protein 2, 36kDa

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205359.2 → NP_990690.2  insulin-like growth factor-binding protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/Swiss-Prot
    P49705
    UniProtKB/TrEMBL
    F1P1I0
    Related
    ENSGALP00010027764.1, ENSGALT00010046621.1
    Conserved Domains (2) summary
    smart00121
    Location:40 → 118
    IB; Insulin growth factor-binding protein homologues
    cd00191
    Location:211 → 291
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22879236..22951723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025152152.2 → XP_025007920.2  insulin-like growth factor-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    Q802T1
    Conserved Domains (1) summary
    cd00191
    Location:114 → 194
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

  2. XM_025152153.2 → XP_025007921.1  insulin-like growth factor-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    Q802T1
    Conserved Domains (1) summary
    cd00191
    Location:89 → 169
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

  3. XM_025152151.2 → XP_025007919.1  insulin-like growth factor-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cd00191
    Location:123 → 203
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

  4. XM_046943498.1 → XP_046799454.1  insulin-like growth factor-binding protein 2 isoform X7

  5. XM_046943497.1 → XP_046799453.1  insulin-like growth factor-binding protein 2 isoform X6

    UniProtKB/TrEMBL
    Q802T1

  6. XM_015289789.3 → XP_015145275.1  insulin-like growth factor-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    Q802T1
    Conserved Domains (1) summary
    pfam00086
    Location:112 → 191
    Thyroglobulin_1; Thyroglobulin type-1 repeat

  7. XM_046943496.1 → XP_046799452.1  insulin-like growth factor-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    Q802T1

  8. XM_046943499.1 → XP_046799455.1  insulin-like growth factor-binding protein 2 isoform X7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22799138..22871611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921150.1 → XP_046777106.1  insulin-like growth factor-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    Q802T1

  2. XM_046921153.1 → XP_046777109.1  insulin-like growth factor-binding protein 2 isoform X5

    UniProtKB/TrEMBL
    Q802T1

  3. XM_046921155.1 → XP_046777111.1  insulin-like growth factor-binding protein 2 isoform X7

  4. XM_046921154.1 → XP_046777110.1  insulin-like growth factor-binding protein 2 isoform X7

  5. XM_046921151.1 → XP_046777107.1  insulin-like growth factor-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    Q802T1

  6. XM_046921152.1 → XP_046777108.1  insulin-like growth factor-binding protein 2 isoform X4

    UniProtKB/TrEMBL
    Q802T1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49705.1 GenPept UniProtKB/Swiss-Prot:P49705

Gene LinkOut

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